Prediction of recurrence after curative resection of hepatocellular carcinoma using liver stiffness measurement (FibroScan®)

Kyu Sik Jung, Seung Up Kim, Gi Hong Choi, Jun Yong Park, Young Nyun Park, Do Young Kim, Sang Hoon Ahn, Chae yoon Chon, Kyung Sik Kim, Eun Hee Choi, Jin Sub Choi, Kwang Hyub Han

Research output: Contribution to journalReview article

34 Citations (Scopus)

Abstract

Background. The purpose of this study was to investigate whether preoperative liver stiffness measurement (LSM) can predict recurrence after curative resection of hepatocellular carcinoma (HCC). LSM using FibroScan can assess the severity of liver fibrosis, which is significantly associated with recurrence after curative resection of HCC. Methods. Between February 2006 and March 2009, 133 patients who underwent preoperative LSM and curative resection for HCC were enrolled in this prospective study. LSM values were analyzed for association with recurrence, together with other clinical variables. Results. The mean age of the patients (117 men and 16 women) was 57 years. During the follow-up period (median, 25.0 (range, 3.0-54.6) months), HCC recurred in 62 (46.6 %) patients. In multivariate analysis, together with satellite nodule and Edmonson-Steiner grade III-IV, LSM was selected as an independent predictor of recurrence (P < 0.05; hazard ratio, 1.034; 95 % confidence interval, 1.007-1.061). When the study population was stratified into two groups using the optimal cutoff value (13.4 kPa) that maximized the sum of sensitivity (64.7 %) and specificity (76.1 %) from time-dependent receiver operating characteristic curves (area unDer the receiver operating characteristic curve = 0.676), patients with LSM values >13.4 kPa were at a significantly greater risk for recurrence with a hazard ratio of 1.925 (P = 0.01; 95 % confidence interval, 1.17-3.168) compared with those with LSM values B13.4 kPa. Conclusions. Our data suggest that LSM can be a useful predictor of recurrence after curative resection of HCC.

Original languageEnglish (US)
Pages (from-to)4278-4286
Number of pages9
JournalAnnals of surgical oncology
Volume19
Issue number13
DOIs
StatePublished - Dec 1 2012

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Hepatocellular Carcinoma
Recurrence
Liver
Liver Cirrhosis
Multivariate Analysis
Prospective Studies
Confidence Intervals

ASJC Scopus subject areas

  • Surgery
  • Oncology

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Prediction of recurrence after curative resection of hepatocellular carcinoma using liver stiffness measurement (FibroScan®). / Jung, Kyu Sik; Kim, Seung Up; Choi, Gi Hong; Park, Jun Yong; Park, Young Nyun; Kim, Do Young; Ahn, Sang Hoon; Chon, Chae yoon; Kim, Kyung Sik; Choi, Eun Hee; Choi, Jin Sub; Han, Kwang Hyub.

In: Annals of surgical oncology, Vol. 19, No. 13, 01.12.2012, p. 4278-4286.

Research output: Contribution to journalReview article

Jung, Kyu Sik ; Kim, Seung Up ; Choi, Gi Hong ; Park, Jun Yong ; Park, Young Nyun ; Kim, Do Young ; Ahn, Sang Hoon ; Chon, Chae yoon ; Kim, Kyung Sik ; Choi, Eun Hee ; Choi, Jin Sub ; Han, Kwang Hyub. / Prediction of recurrence after curative resection of hepatocellular carcinoma using liver stiffness measurement (FibroScan®). In: Annals of surgical oncology. 2012 ; Vol. 19, No. 13. pp. 4278-4286.
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title = "Prediction of recurrence after curative resection of hepatocellular carcinoma using liver stiffness measurement (FibroScan{\circledR})",
abstract = "Background. The purpose of this study was to investigate whether preoperative liver stiffness measurement (LSM) can predict recurrence after curative resection of hepatocellular carcinoma (HCC). LSM using FibroScan can assess the severity of liver fibrosis, which is significantly associated with recurrence after curative resection of HCC. Methods. Between February 2006 and March 2009, 133 patients who underwent preoperative LSM and curative resection for HCC were enrolled in this prospective study. LSM values were analyzed for association with recurrence, together with other clinical variables. Results. The mean age of the patients (117 men and 16 women) was 57 years. During the follow-up period (median, 25.0 (range, 3.0-54.6) months), HCC recurred in 62 (46.6 {\%}) patients. In multivariate analysis, together with satellite nodule and Edmonson-Steiner grade III-IV, LSM was selected as an independent predictor of recurrence (P < 0.05; hazard ratio, 1.034; 95 {\%} confidence interval, 1.007-1.061). When the study population was stratified into two groups using the optimal cutoff value (13.4 kPa) that maximized the sum of sensitivity (64.7 {\%}) and specificity (76.1 {\%}) from time-dependent receiver operating characteristic curves (area unDer the receiver operating characteristic curve = 0.676), patients with LSM values >13.4 kPa were at a significantly greater risk for recurrence with a hazard ratio of 1.925 (P = 0.01; 95 {\%} confidence interval, 1.17-3.168) compared with those with LSM values B13.4 kPa. Conclusions. Our data suggest that LSM can be a useful predictor of recurrence after curative resection of HCC.",
author = "Jung, {Kyu Sik} and Kim, {Seung Up} and Choi, {Gi Hong} and Park, {Jun Yong} and Park, {Young Nyun} and Kim, {Do Young} and Ahn, {Sang Hoon} and Chon, {Chae yoon} and Kim, {Kyung Sik} and Choi, {Eun Hee} and Choi, {Jin Sub} and Han, {Kwang Hyub}",
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TY - JOUR

T1 - Prediction of recurrence after curative resection of hepatocellular carcinoma using liver stiffness measurement (FibroScan®)

AU - Jung, Kyu Sik

AU - Kim, Seung Up

AU - Choi, Gi Hong

AU - Park, Jun Yong

AU - Park, Young Nyun

AU - Kim, Do Young

AU - Ahn, Sang Hoon

AU - Chon, Chae yoon

AU - Kim, Kyung Sik

AU - Choi, Eun Hee

AU - Choi, Jin Sub

AU - Han, Kwang Hyub

PY - 2012/12/1

Y1 - 2012/12/1

N2 - Background. The purpose of this study was to investigate whether preoperative liver stiffness measurement (LSM) can predict recurrence after curative resection of hepatocellular carcinoma (HCC). LSM using FibroScan can assess the severity of liver fibrosis, which is significantly associated with recurrence after curative resection of HCC. Methods. Between February 2006 and March 2009, 133 patients who underwent preoperative LSM and curative resection for HCC were enrolled in this prospective study. LSM values were analyzed for association with recurrence, together with other clinical variables. Results. The mean age of the patients (117 men and 16 women) was 57 years. During the follow-up period (median, 25.0 (range, 3.0-54.6) months), HCC recurred in 62 (46.6 %) patients. In multivariate analysis, together with satellite nodule and Edmonson-Steiner grade III-IV, LSM was selected as an independent predictor of recurrence (P < 0.05; hazard ratio, 1.034; 95 % confidence interval, 1.007-1.061). When the study population was stratified into two groups using the optimal cutoff value (13.4 kPa) that maximized the sum of sensitivity (64.7 %) and specificity (76.1 %) from time-dependent receiver operating characteristic curves (area unDer the receiver operating characteristic curve = 0.676), patients with LSM values >13.4 kPa were at a significantly greater risk for recurrence with a hazard ratio of 1.925 (P = 0.01; 95 % confidence interval, 1.17-3.168) compared with those with LSM values B13.4 kPa. Conclusions. Our data suggest that LSM can be a useful predictor of recurrence after curative resection of HCC.

AB - Background. The purpose of this study was to investigate whether preoperative liver stiffness measurement (LSM) can predict recurrence after curative resection of hepatocellular carcinoma (HCC). LSM using FibroScan can assess the severity of liver fibrosis, which is significantly associated with recurrence after curative resection of HCC. Methods. Between February 2006 and March 2009, 133 patients who underwent preoperative LSM and curative resection for HCC were enrolled in this prospective study. LSM values were analyzed for association with recurrence, together with other clinical variables. Results. The mean age of the patients (117 men and 16 women) was 57 years. During the follow-up period (median, 25.0 (range, 3.0-54.6) months), HCC recurred in 62 (46.6 %) patients. In multivariate analysis, together with satellite nodule and Edmonson-Steiner grade III-IV, LSM was selected as an independent predictor of recurrence (P < 0.05; hazard ratio, 1.034; 95 % confidence interval, 1.007-1.061). When the study population was stratified into two groups using the optimal cutoff value (13.4 kPa) that maximized the sum of sensitivity (64.7 %) and specificity (76.1 %) from time-dependent receiver operating characteristic curves (area unDer the receiver operating characteristic curve = 0.676), patients with LSM values >13.4 kPa were at a significantly greater risk for recurrence with a hazard ratio of 1.925 (P = 0.01; 95 % confidence interval, 1.17-3.168) compared with those with LSM values B13.4 kPa. Conclusions. Our data suggest that LSM can be a useful predictor of recurrence after curative resection of HCC.

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U2 - 10.1245/s10434-012-2422-3

DO - 10.1245/s10434-012-2422-3

M3 - Review article

C2 - 22752370

AN - SCOPUS:84875619003

VL - 19

SP - 4278

EP - 4286

JO - Annals of Surgical Oncology

JF - Annals of Surgical Oncology

SN - 1068-9265

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