Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy

Gui Ming Zhang, Yao Zhu, Lei Luo, Fang Ning Wan, Yi Ping Zhu, Li Jiang Sun, Ding Wei Ye

    Research output: Contribution to journalArticle

    56 Scopus citations

    Abstract

    Although pretreatment neutrophil–lymphocyte ratio (NLR), lymphocyte–monocyte ratio (LMR), and platelet–lymphocyte ratio (PLR) are reportedly associated with clinical outcomes of many cancers, their roles in patients with bladder cancer (BCa) who undergo radical cystectomy (RC) have not been widely investigated. We analyzed relationships between preoperative NLR, LMR, PLR, and overall survival (OS) in 124 BCa patients undergoing RC. OS curves were drawn using the Kaplan–Meier method and evaluated using the log-rank test. Relationships between OS and potential confounding variables were determined using Cox’s proportional hazard regression model. Decreased LMR was associated with shorter OS (P = 0.012); OS in the low PLR group was significantly longer than that in the high PLR group (P = 0.029), and NLR was not significantly associated with oncological outcomes. However, after adjusting for confounding variables, patients in the high-LMR group indicated >30 % decreased mortality than the low-LMR group (hazard ratio 0.674; 95 % confidence interval 0.412–0.890; P = 0.003), and PLR was not an independent predictor of OS. Our results show that preoperative LMR is a better prognostic factor in BCa patients undergoing RC, compared with NLR and PLR.

    Original languageEnglish (US)
    Pages (from-to)8537-8543
    Number of pages7
    JournalTumor Biology
    Volume36
    Issue number11
    DOIs
    StatePublished - Nov 1 2015

    Keywords

    • Bladder cancer
    • LMR
    • NLR
    • PLR
    • Prognosis
    • Radical cystectomy

    ASJC Scopus subject areas

    • Cancer Research

    Fingerprint Dive into the research topics of 'Preoperative lymphocyte-monocyte and platelet-lymphocyte ratios as predictors of overall survival in patients with bladder cancer undergoing radical cystectomy'. Together they form a unique fingerprint.

  • Cite this