@inbook{884baeee57934b4c9a78028e674a2fa0,
title = "Preprocessing and analysis of LC-MS-based proteomic data",
abstract = "Liquid chromatography coupled with mass spectrometry (LC-MS) has been widely used for profiling protein expression levels. This chapter is focused on LC-MS data preprocessing, which is a crucial step in the analysis of LC-MS based proteomics. We provide a high-level overview, highlight associated challenges, and present a step-by-step example for analysis of data from LC-MS based untargeted proteomic study. Furthermore, key procedures and relevant issues with the subsequent analysis by multiple reaction monitoring (MRM) are discussed.",
keywords = "Data preprocessing, Label-free, Liquid chromatography-mass spectrometry (LC-MS), Multiple reaction monitoring (MRM), Proteomics",
author = "Tsai, {Tsung Heng} and Minkun Wang and Ressom, {Habtom W.}",
note = "Publisher Copyright: {\textcopyright} Springer Science+Business Media New York 2016.",
year = "2016",
doi = "10.1007/978-1-4939-3106-4_3",
language = "English (US)",
series = "Methods in Molecular Biology",
publisher = "Humana Press Inc.",
pages = "63--76",
booktitle = "Methods in Molecular Biology",
}