Pretreatment SUVmax may influence the clinical benefit of BR over R-CHOP in patients with previously untreated FL

Paolo Strati, Mohamed Amin Ahmed, Loretta J. Nastoupil, Lei Feng, Fredrick B. Hagemeister, Luis E. Fayad, Maria A. Rodriguez, Felipe Samaniego, Michael Wang, Jason R. Westin, Hun J. Lee, Swaminathan P. Iyer, Simrit Parmar, Sairah Ahmed, Ranjit Nair, Raphael E. Steiner, Mansoor Noorani, Christopher R. Flowers, R. Eric Davis, Nathan H. FowlerSattva S. Neelapu

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

In 2 randomized phase 3 trials BR resulted in longer progression-free survival (PFS) than frontline R-CHOP in patients with indolent and mantle cell lymphoma. However, in subset analyses of follicular lymphoma (FL), the results were incongruent. We conducted a retrospective matched-pair analysis to compare the outcome of patients with advanced stage FL, receiving frontline BR (N = 73) or R-CHOP (N = 73), matched by age, gender, stage, and FL International Prognostic Index score. On multivariable analysis, baseline maximum standardized uptake value (SUVmax) >13 was associated with use of R-CHOP (p =.001). After a median follow-up of 69 months for the BR arm and 126 months for the R-CHOP arm, 5-year PFS was 80% and 70%, respectively (p =.07). After adjusting for SUVmax >13, the trend for better PFS in BR was not maintained. Prospective studies are needed to validate the role of pretreatment SUVmax as a stratification factor in future randomized therapeutic trials in FL.

Original languageEnglish (US)
Pages (from-to)1380-1387
Number of pages8
JournalLeukemia and Lymphoma
Volume61
Issue number6
DOIs
StatePublished - May 11 2020

Keywords

  • BR
  • FL
  • RCHOP
  • SUV

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

MD Anderson CCSG core facilities

  • Biostatistics Resource Group

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