Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes

Fabio Efficace; Gianluca Gaidano; Massimo Breccia; Marianna Criscuolo; Francesco Cottone; Giovanni Caocci; David Bowen; Michael Lübbert; Emanuele Angelucci; Reinhard Stauder; Dominik Selleslag; Uwe Platzbecker; Grazia Sanpaolo; Anna Jonasova; Francesco Buccisano; Giorgina Specchia; Giuseppe A. Palumbo; Pasquale Niscola; Chonghua Wan; Huiyong Zhang; Susanna Fenu; Virginia Klimek; Odile Beyne-Rauzy; Khanh Nguyen; Franco Mandelli

doi:10.1111/bjh.13138

Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes

Fabio Efficace, Gianluca Gaidano, Massimo Breccia, Marianna Criscuolo, Francesco Cottone, Giovanni Caocci, David Bowen, Michael Lübbert, Emanuele Angelucci, Reinhard Stauder, Dominik Selleslag, Uwe Platzbecker, Grazia Sanpaolo, Anna Jonasova, Francesco Buccisano, Giorgina Specchia, Giuseppe A. Palumbo, Pasquale Niscola, Chonghua Wan, Huiyong ZhangSusanna Fenu, Virginia Klimek, Odile Beyne-Rauzy, Khanh Nguyen, Franco Mandelli

Research output: Contribution to journal › Article › peer-review

57 Scopus citations

Abstract

The primary objective of this study was to investigate factors associated with fatigue severity in newly diagnosed patients with higher-risk myelodysplastic syndromes (MDS). The secondary objectives were to assess symptom prevalence and to examine the relationships between fatigue, quality of life (QoL) and overall symptom burden in these patients. The analyses were conducted in 280 higher-risk MDS patients. Pre-treatment patient-reported fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale and QoL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Female gender (P = 0·018), poor performance status (i.e., ECOG of 2-4) (P < 0·001) and lower levels of haemoglobin (Hb) (P = 0·026) were independently associated with higher fatigue severity. The three most prevalent symptoms were as follows: fatigue (92%), dyspnoea (63%) and pain (55%). Patients with higher levels of fatigue also had greater overall symptom burdens. The mean global QoL scores of patients with the highest versus those with the lowest levels of fatigue were 29·2 [standard deviation (SD), 18·3] and 69·0 (SD, 18·8), respectively and this difference was four times the magnitude of a clinically meaningful difference. Patient-reported fatigue severity revealed the effects of disease burden on overall QoL more accurately than did degree of anaemia. Special attention should be given to the female patients in the management of fatigue.

Original language	English (US)
Pages (from-to)	361-370
Number of pages	10
Journal	British Journal of Haematology
Volume	168
Issue number	3
DOIs	https://doi.org/10.1111/bjh.13138
State	Published - Feb 1 2015

Keywords

Anaemia
Fatigue
Haemoglobin
Myelodysplastic syndromes
Quality of life

ASJC Scopus subject areas

Hematology

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10.1111/bjh.13138

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Efficace, F., Gaidano, G., Breccia, M., Criscuolo, M., Cottone, F., Caocci, G., Bowen, D., Lübbert, M., Angelucci, E., Stauder, R., Selleslag, D., Platzbecker, U., Sanpaolo, G., Jonasova, A., Buccisano, F., Specchia, G., Palumbo, G. A., Niscola, P., Wan, C., ... Mandelli, F. (2015). Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes. British Journal of Haematology, 168(3), 361-370. https://doi.org/10.1111/bjh.13138

Efficace, F, Gaidano, G, Breccia, M, Criscuolo, M, Cottone, F, Caocci, G, Bowen, D, Lübbert, M, Angelucci, E, Stauder, R, Selleslag, D, Platzbecker, U, Sanpaolo, G, Jonasova, A, Buccisano, F, Specchia, G, Palumbo, GA, Niscola, P, Wan, C, Zhang, H, Fenu, S, Klimek, V, Beyne-Rauzy, O, Nguyen, K & Mandelli, F 2015, 'Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes', British Journal of Haematology, vol. 168, no. 3, pp. 361-370. https://doi.org/10.1111/bjh.13138

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abstract = "The primary objective of this study was to investigate factors associated with fatigue severity in newly diagnosed patients with higher-risk myelodysplastic syndromes (MDS). The secondary objectives were to assess symptom prevalence and to examine the relationships between fatigue, quality of life (QoL) and overall symptom burden in these patients. The analyses were conducted in 280 higher-risk MDS patients. Pre-treatment patient-reported fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale and QoL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Female gender (P = 0·018), poor performance status (i.e., ECOG of 2-4) (P < 0·001) and lower levels of haemoglobin (Hb) (P = 0·026) were independently associated with higher fatigue severity. The three most prevalent symptoms were as follows: fatigue (92%), dyspnoea (63%) and pain (55%). Patients with higher levels of fatigue also had greater overall symptom burdens. The mean global QoL scores of patients with the highest versus those with the lowest levels of fatigue were 29·2 [standard deviation (SD), 18·3] and 69·0 (SD, 18·8), respectively and this difference was four times the magnitude of a clinically meaningful difference. Patient-reported fatigue severity revealed the effects of disease burden on overall QoL more accurately than did degree of anaemia. Special attention should be given to the female patients in the management of fatigue.",

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AU - Efficace, Fabio

AU - Gaidano, Gianluca

AU - Breccia, Massimo

AU - Criscuolo, Marianna

AU - Cottone, Francesco

AU - Caocci, Giovanni

AU - Bowen, David

AU - Lübbert, Michael

AU - Angelucci, Emanuele

AU - Stauder, Reinhard

AU - Selleslag, Dominik

AU - Platzbecker, Uwe

AU - Sanpaolo, Grazia

AU - Jonasova, Anna

AU - Buccisano, Francesco

AU - Specchia, Giorgina

AU - Palumbo, Giuseppe A.

AU - Niscola, Pasquale

AU - Wan, Chonghua

AU - Zhang, Huiyong

AU - Fenu, Susanna

AU - Klimek, Virginia

AU - Beyne-Rauzy, Odile

AU - Nguyen, Khanh

AU - Mandelli, Franco

PY - 2015/2/1

Y1 - 2015/2/1

N2 - The primary objective of this study was to investigate factors associated with fatigue severity in newly diagnosed patients with higher-risk myelodysplastic syndromes (MDS). The secondary objectives were to assess symptom prevalence and to examine the relationships between fatigue, quality of life (QoL) and overall symptom burden in these patients. The analyses were conducted in 280 higher-risk MDS patients. Pre-treatment patient-reported fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale and QoL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Female gender (P = 0·018), poor performance status (i.e., ECOG of 2-4) (P < 0·001) and lower levels of haemoglobin (Hb) (P = 0·026) were independently associated with higher fatigue severity. The three most prevalent symptoms were as follows: fatigue (92%), dyspnoea (63%) and pain (55%). Patients with higher levels of fatigue also had greater overall symptom burdens. The mean global QoL scores of patients with the highest versus those with the lowest levels of fatigue were 29·2 [standard deviation (SD), 18·3] and 69·0 (SD, 18·8), respectively and this difference was four times the magnitude of a clinically meaningful difference. Patient-reported fatigue severity revealed the effects of disease burden on overall QoL more accurately than did degree of anaemia. Special attention should be given to the female patients in the management of fatigue.

AB - The primary objective of this study was to investigate factors associated with fatigue severity in newly diagnosed patients with higher-risk myelodysplastic syndromes (MDS). The secondary objectives were to assess symptom prevalence and to examine the relationships between fatigue, quality of life (QoL) and overall symptom burden in these patients. The analyses were conducted in 280 higher-risk MDS patients. Pre-treatment patient-reported fatigue was evaluated with the Functional Assessment of Chronic Illness Therapy (FACIT)-Fatigue scale and QoL was assessed with the European Organization for Research and Treatment of Cancer Quality of Life Questionnaire-Core 30 (EORTC QLQ-C30). Female gender (P = 0·018), poor performance status (i.e., ECOG of 2-4) (P < 0·001) and lower levels of haemoglobin (Hb) (P = 0·026) were independently associated with higher fatigue severity. The three most prevalent symptoms were as follows: fatigue (92%), dyspnoea (63%) and pain (55%). Patients with higher levels of fatigue also had greater overall symptom burdens. The mean global QoL scores of patients with the highest versus those with the lowest levels of fatigue were 29·2 [standard deviation (SD), 18·3] and 69·0 (SD, 18·8), respectively and this difference was four times the magnitude of a clinically meaningful difference. Patient-reported fatigue severity revealed the effects of disease burden on overall QoL more accurately than did degree of anaemia. Special attention should be given to the female patients in the management of fatigue.

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KW - Haemoglobin

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Prevalence, severity and correlates of fatigue in newly diagnosed patients with myelodysplastic syndromes

Abstract

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