Primary small cell carcinoma of the esophagus: Clinicopathological study of 44 cases

Wei Wei Chen, Feng Wang, Dong Sheng Zhang, Hui Yan Luo, Zhi Qiang Wang, Feng Hua Wang, Miao Zhen Qiu, Chao Ren, Xiao Li Wei, Wen Jing Wu, Yu Hong Li, Rui Hua Xu

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Background: Primary small cell carcinoma of the esophagus (SCCE) is a highly aggressive disease characterized by early dissemination and poor prognosis. Because of the rarity of this disease, few previous studies have investigated the biomarkers associated with its prognosis. Leucine-rich repeat-containing G-protein coupled receptor 5 (Lgr5) is a stem cell marker and a member of the canonical Wnt-signaling cascade. However, the clinical role of Lgr5 in SCCE remains unknown.Methods: Tissue sections were obtained from 44 patients diagnosed with SCCE and expression of Lgr5 was examined by immunohistochemistry. The correlations between Lgr5 expression, and clinical parameters and prognostic significance were evaluated.Results: Lgr5 was expressed in SCCE cancer tissues. High Lgr5 expression was significantly correlated with lymph node metastasis (p = 0.003), late stage (p = 0.003) and unfavorable response to chemotherapy (p = 0.013) according to RECIST 1.0 criteria. Patients with higher Lgr5 expression levels had shorter overall survival times than those with lower expression levels.Conclusions: These results demonstrated that overexpression of Lgr5 was significantly correlated with lymph node metastasis, tumor stage, and response to chemotherapy. Furthermore, high levels of Lgr5 expression appeared to be associated with poorer survival in patients with SCCE.

Original languageEnglish (US)
Article number222
JournalBMC cancer
Volume14
Issue number1
DOIs
StatePublished - Mar 25 2014

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Small Cell Carcinoma
Esophagus
Lymph Nodes
Neoplasm Metastasis
Drug Therapy
Survival
Esophageal Neoplasms
G-Protein-Coupled Receptors
Leucine
Stem Cells
Biomarkers
Immunohistochemistry
Neoplasms

Keywords

  • Esophagus
  • Lgr5
  • Prognosis
  • Small cell carcinoma

ASJC Scopus subject areas

  • Genetics
  • Oncology
  • Cancer Research

Cite this

Chen, W. W., Wang, F., Zhang, D. S., Luo, H. Y., Wang, Z. Q., Wang, F. H., ... Xu, R. H. (2014). Primary small cell carcinoma of the esophagus: Clinicopathological study of 44 cases. BMC cancer, 14(1), [222]. https://doi.org/10.1186/1471-2407-14-222

Primary small cell carcinoma of the esophagus : Clinicopathological study of 44 cases. / Chen, Wei Wei; Wang, Feng; Zhang, Dong Sheng; Luo, Hui Yan; Wang, Zhi Qiang; Wang, Feng Hua; Qiu, Miao Zhen; Ren, Chao; Wei, Xiao Li; Wu, Wen Jing; Li, Yu Hong; Xu, Rui Hua.

In: BMC cancer, Vol. 14, No. 1, 222, 25.03.2014.

Research output: Contribution to journalArticle

Chen, WW, Wang, F, Zhang, DS, Luo, HY, Wang, ZQ, Wang, FH, Qiu, MZ, Ren, C, Wei, XL, Wu, WJ, Li, YH & Xu, RH 2014, 'Primary small cell carcinoma of the esophagus: Clinicopathological study of 44 cases', BMC cancer, vol. 14, no. 1, 222. https://doi.org/10.1186/1471-2407-14-222
Chen, Wei Wei ; Wang, Feng ; Zhang, Dong Sheng ; Luo, Hui Yan ; Wang, Zhi Qiang ; Wang, Feng Hua ; Qiu, Miao Zhen ; Ren, Chao ; Wei, Xiao Li ; Wu, Wen Jing ; Li, Yu Hong ; Xu, Rui Hua. / Primary small cell carcinoma of the esophagus : Clinicopathological study of 44 cases. In: BMC cancer. 2014 ; Vol. 14, No. 1.
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