Principles of blood separation and component extraction in a disposable continuous-flow single-stage channel

J. P. Hester; R. M. Kellogg; A. P. Mulzet; V. R. Kruger; K. B. McCredie; E. J. Freireich

doi:10.1182/blood.v54.1.254.254

Principles of blood separation and component extraction in a disposable continuous-flow single-stage channel

J. P. Hester, R. M. Kellogg, A. P. Mulzet, V. R. Kruger, K. B. McCredie, E. J. Freireich

Leukemia

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

A single-stage disposable channel and seal that provides for leukocyte and granulocyte collection by continuous-flow cell separation (CFCS) has been designated by the IRM Corporation. This paper describes (1) the separation characteristics of whole blood as it responds to varying gravitational (G) forces and flow through the channel; (2) the mechanism by which the buffy coat accumulates and is extracted; (3) the efficiency of extraction; (4) those donor and procedural variables that contribute to the final yield; (5) posttransfusion increment response in patients; and (6) the functional integrity of the cells collected.

Original language	English (US)
Pages (from-to)	254-268
Number of pages	15
Journal	Unknown Journal
Volume	54
Issue number	1
DOIs	https://doi.org/10.1182/blood.v54.1.254.254
State	Published - 1979

ASJC Scopus subject areas

Biochemistry
Immunology
Hematology
Cell Biology

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10.1182/blood.v54.1.254.254

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abstract = "A single-stage disposable channel and seal that provides for leukocyte and granulocyte collection by continuous-flow cell separation (CFCS) has been designated by the IRM Corporation. This paper describes (1) the separation characteristics of whole blood as it responds to varying gravitational (G) forces and flow through the channel; (2) the mechanism by which the buffy coat accumulates and is extracted; (3) the efficiency of extraction; (4) those donor and procedural variables that contribute to the final yield; (5) posttransfusion increment response in patients; and (6) the functional integrity of the cells collected.",

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Principles of blood separation and component extraction in a disposable continuous-flow single-stage channel

Abstract

ASJC Scopus subject areas

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