Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007

Gordon F. Schwartz; Kevin S. Hughes; Henry T. Lynch; Carol J. Fabian; Ian S. Fentiman; Mark E. Robson; Susan M. Domchek; Lynn C. Hartmann; Roland Holland; David J. Winchester; Benjamin O. Anderson; Banu K. Arun; Harry Bartolink; Philip Bernard; Bernardo Bonanni; Blake Cady; Krishna B. Clough; Stephen A. Feig; Sylvia H. Heywang-Kobrunner; Anthony Howell; Claudine Isaacs; Daniel B. Kopans; Robert E. Mansel; Shahla Masood; Juan P. Palazzo; Lawrence J. Solin; Michael Untch

doi:10.1002/cncr.23903

Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007

Gordon F. Schwartz, Kevin S. Hughes, Henry T. Lynch, Carol J. Fabian, Ian S. Fentiman, Mark E. Robson, Susan M. Domchek, Lynn C. Hartmann, Roland Holland, David J. Winchester, Benjamin O. Anderson, Banu K. Arun, Harry Bartolink, Philip Bernard, Bernardo Bonanni, Blake Cady, Krishna B. Clough, Stephen A. Feig, Sylvia H. Heywang-Kobrunner, Anthony HowellClaudine Isaacs, Daniel B. Kopans, Robert E. Mansel, Shahla Masood, Juan P. Palazzo, Lawrence J. Solin, Michael Untch

Breast Medical Oncology

Research output: Contribution to journal › Article › peer-review

84 Scopus citations

Abstract

A consensus conference including 30 experts was held in April, 2007, to discuss risk factors for breast cancer and their management. Four categories of risk were outlined, from "average" through "very high" risk, the latter including individuals with high penetrance BRCA1/2 gene mutations. Guidelines for management of patients in each of these categories were discussed, with the major portion of the conference devoted to individuals with BRCA1/2 mutations. Prevalence of these mutations in the general population was estimated to be 1 in 250-500 individuals, with an increased prevalence in Ashkenazi Jews and other founder groups. Risk-reduction strategies for these individuals included surveillance, with or without chemoprevention drugs, or surgical procedures to remove the organs at risk, ie, bilateral mastectomy and/or bilateral salpingo-oophorectomy. These risk reduction strategies were evaluated fully, and recommendations were made for the care of patients in each risk category. These guidelines for patient care were approved by the entire group of experts.

Original language	English (US)
Pages (from-to)	2627-2637
Number of pages	11
Journal	Cancer
Volume	113
Issue number	10
DOIs	https://doi.org/10.1002/cncr.23903
State	Published - Nov 15 2008

Keywords

BRCA mutations
Breast cancer
International conference
Patient management guidelines
Risk factors

ASJC Scopus subject areas

Oncology
Cancer Research

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10.1002/cncr.23903

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Schwartz, G. F., Hughes, K. S., Lynch, H. T., Fabian, C. J., Fentiman, I. S., Robson, M. E., Domchek, S. M., Hartmann, L. C., Holland, R., Winchester, D. J., Anderson, B. O., Arun, B. K., Bartolink, H., Bernard, P., Bonanni, B., Cady, B., Clough, K. B., Feig, S. A., Heywang-Kobrunner, S. H., ... Untch, M. (2008). Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007. Cancer, 113(10), 2627-2637. https://doi.org/10.1002/cncr.23903

Schwartz, GF, Hughes, KS, Lynch, HT, Fabian, CJ, Fentiman, IS, Robson, ME, Domchek, SM, Hartmann, LC, Holland, R, Winchester, DJ, Anderson, BO, Arun, BK, Bartolink, H, Bernard, P, Bonanni, B, Cady, B, Clough, KB, Feig, SA, Heywang-Kobrunner, SH, Howell, A, Isaacs, C, Kopans, DB, Mansel, RE, Masood, S, Palazzo, JP, Solin, LJ & Untch, M 2008, 'Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007', Cancer, vol. 113, no. 10, pp. 2627-2637. https://doi.org/10.1002/cncr.23903

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AU - Isaacs, Claudine

AU - Kopans, Daniel B.

AU - Mansel, Robert E.

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AU - Solin, Lawrence J.

AU - Untch, Michael

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Proceedings of the International Consensus Conference on Breast Cancer Risk, Genetics, & Risk Management, April, 2007

Abstract

Keywords

ASJC Scopus subject areas

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