Profiling the immune responses in patient sera with peptide and cDNA display libraries.

Mouldi Sioud, M. Hansen, A. Dybwad

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

Peptide and cDNA phage display libraries can be used to determine the specificities of antibodies present in the whole sera of patients where information about the parental antigens is unknown. In this respect, patient serum antibody binding ligands have been identified. Such ligands would facilitate the design of diagnostic assays and therapeutic vaccines. In the case of cancer, this novel technology is expected to improve our understanding of the immune responses against tumour cells and to discriminate between autoantigen and true tumour specific antigens. Here, we review work on how peptide and cDNA phage display libraries can be used to address the specificity of the immune responses in patients with autoimmune diseases and cancer.

Original languageEnglish (US)
Pages (from-to)123-128
Number of pages6
JournalInternational Journal of Molecular Medicine
Volume6
Issue number2
StatePublished - Jan 1 2000

Fingerprint

Gene Library
Peptide Library
Peptides
Complementary DNA
Serum
Ligands
Neoplasms
Antibody Specificity
Autoantigens
Neoplasm Antigens
Autoimmune Diseases
Vaccines
Technology
Antigens
Antibodies
Therapeutics

ASJC Scopus subject areas

  • Genetics

Cite this

Profiling the immune responses in patient sera with peptide and cDNA display libraries. / Sioud, Mouldi; Hansen, M.; Dybwad, A.

In: International Journal of Molecular Medicine, Vol. 6, No. 2, 01.01.2000, p. 123-128.

Research output: Contribution to journalReview article

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