Prognostic factors and characteristics of pancreatic neuroendocrine tumors: Single center experience

Tak Geun Oh, Moon Jae Chung, Jeong Yeop Park, Seung Min Bang, Seung Woo Park, Jae Bok Chung, Si Young Song

    Research output: Contribution to journalArticle

    16 Scopus citations

    Abstract

    Purpose: Pancreatic neuroendocrine tumors (PNET) are a rare subgroup of tumors. For PNETs, the predictive factors for survival and prognosis are not well known. The purpose of our study was to evaluate the predictive factors for survival and disease progression in PNETs. Materials and Methods: We retrospectively analyzed 37 patients who were diagnosed with PNET at Severance Hospital between November 2005 and March 2010. Prognostic factors for survival and disease progression were evaluated using the Kaplan-Meier method. Results: The mean age of the patients was 50.0±15.0 years. Eight cases (21.6%) were described as functioning tumors and 29 cases (78.4%) as non-functioning tumors. In univariate analysis of clinical factors, patients with liver metastasis (p=0.002), without resection of primary tumors (p=0.002), or American Joint Committee on Cancer/Union for International Cancer Control (AJCC/UICC) stage III/IV (p=0.002) were more likely to demonstrate shorter overall survival (OS). Patients with bile duct or pancreatic duct invasion (p=0.031), sized-lesions larger than 20 mm (p=0.036), liver metastasis (p=0.020), distant metastasis (p=0.005), lymph node metastasis (p=0.009) or without resection of primary tumors (p=0.020) were more likely to demonstrate shorter progression-free survival (PFS). In multivariate analysis of clinical factors, bile duct or pancreatic duct invasion [p=0.010, hazard ratio (HR)=95.046] and tumor location (non-head of pancreas) (p=0.036, HR=7.381) were confirmed as independent factors for predicting shorter PFS. Conclusion: Patients with liver metastasis or without resection of primary tumors were more likely to demonstrate shorter OS. Patients with bile duct or pancreatic duct invasion or tumors located at body or tail of pancreas were more likely to demonstrate shorter PFS.

    Original languageEnglish (US)
    Pages (from-to)944-951
    Number of pages8
    JournalYonsei medical journal
    Volume53
    Issue number5
    DOIs
    StatePublished - Jul 2012

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    Keywords

    • Bile duct invasion
    • Liver metastasis
    • Location of tumor
    • Pancreatic duct invasion
    • Pancreatic neuroendocrine tumor
    • Prognostic factor

    ASJC Scopus subject areas

    • Medicine(all)

    Cite this

    Oh, T. G., Chung, M. J., Park, J. Y., Bang, S. M., Park, S. W., Chung, J. B., & Song, S. Y. (2012). Prognostic factors and characteristics of pancreatic neuroendocrine tumors: Single center experience. Yonsei medical journal, 53(5), 944-951. https://doi.org/10.3349/ymj.2012.53.5.944