Prognostic factors and survival in patients with squamous cell carcinoma lymph nodes metastases from an unknown primary to the head and neck

Shi Min Zhuang, Ji Zhang, Shu Wei Chen, Huan Li, Ming Song

Research output: Contribution to journalArticle

Abstract

Purpose: To analyze the clinicopathological characteristics, treatment modalities, and potential prognostic factors of cancer of unknown primary tumor (CUP) in a consecutivegroup cases. Methods: This retrospective study enrolled consecutive patients who were admitted to the Sun Yat-senUniversity Cancer Center between 1980 and 2011. Results: The key prognostic factors influencing the survival were the lymph nodes extracapsular extension (ECE), N classification, recurrence, emergence of primary tumor and treatment modalities. Multivariate analysis revealed that N classification and recurrence were independent risk factor for patient survival. Conclusions: N classification and recurrence were independent prognostic factor that influenced the treatment outcome. Our data indicate that combined surgery and postoperative radiotherapy for CUP offers the best chance for long-term survival.

Original languageEnglish (US)
Pages (from-to)5828-5834
Number of pages7
JournalInternational Journal of Clinical and Experimental Medicine
Volume9
Issue number3
StatePublished - Mar 30 2016

Fingerprint

Tumors
Squamous Cell Carcinoma
Neck
Unknown Primary Neoplasms
Lymph Nodes
Head
Neoplasm Metastasis
Survival
Recurrence
Neoplasms
Radiotherapy
Sun
Surgery
Solar System
Multivariate Analysis
Retrospective Studies
Epithelial Cells
Therapeutics

Keywords

  • Cervical lymph node metastases
  • Radiotherapy
  • Squamous cell carcinoma
  • Surgery
  • Unknown primary tumor

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Prognostic factors and survival in patients with squamous cell carcinoma lymph nodes metastases from an unknown primary to the head and neck. / Zhuang, Shi Min; Zhang, Ji; Chen, Shu Wei; Li, Huan; Song, Ming.

In: International Journal of Clinical and Experimental Medicine, Vol. 9, No. 3, 30.03.2016, p. 5828-5834.

Research output: Contribution to journalArticle

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