Prognostic Factors for Survival in Melanoma Patients with Brain Metastases

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Scopus citations

Abstract

Melanoma is the most aggressive form of skin cancer. One of the most common and devastating complications of advanced melanoma is the development of metastases to the central nervous system (CNS). Historically outcomes in patients with melanoma brain metastases have been dismal. However, an improved understanding of the molecular pathogenesis of this disease has recently led to the development of multiple new therapies with unprecedented clinical efficacy, generating optimism that significant improvements in long-term patient survival are achievable. Achieving this goal will require improved prevention and treatment of CNS metastases. To set the stage for the appropriate design and interpretation of clinical trials in this area, this chapter will review and integrate existing data about clinical and molecular factors that predict the development, survival, and treatment outcomes of melanoma patients with brain metastases.

Original languageEnglish (US)
Title of host publicationBrain Metastases from Primary Tumors
Subtitle of host publicationEpidemiology, Biology, and Therapy of Melanoma and Other Cancers
PublisherElsevier Inc.
Pages267-297
Number of pages31
Volume3
ISBN (Electronic)9780128035597
ISBN (Print)9780128035085
DOIs
StatePublished - Apr 27 2016

Keywords

  • Brain metastases
  • Central nervous system (CNS)
  • Melanoma
  • Radiation
  • Skin cancer
  • Surgery
  • Systemic treatment

ASJC Scopus subject areas

  • Medicine(all)

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