Prognostic factors of pulmonary metastasectomy for osteosarcomas of the extremities

Fengshi Chen, Ryo Miyahara, Toru Bando, Kenichi Okubo, Kenichiro Watanabe, Tomitaka Nakayama, Junya Toguchida, Hiroshi Date

    Research output: Contribution to journalArticle

    21 Scopus citations

    Abstract

    Background: Factors affecting recurrence and survival after pulmonary resection for metastatic osteosarcomas are controversial. To confirm a role for resection of pulmonary metastases for such tumors, we herein reviewed our institutional experience. Methods: Between 1989 and 2007, 23 patients with pulmonary metastases from osteosarcomas of the extremities underwent pulmonary resection. Various perioperative variables were investigated retrospectively to confirm a role for metastasectomy and to analyze prognostic factors for overall survival and disease-free survival after metastasectomy. Results: Overall survival rate after metastasectomy was 31% at 5 years. Disease-free survival rate was 19% at 5 years after pulmonary resection. On multivariate analysis, patients with less than five pulmonary metastases and patients without pulmonary metastases identified during pre- and postoperative chemotherapy presented significantly favorable overall survival (p = 0.015 and 0.0082, respectively). Furthermore, the number of pulmonary metastases less than five was the only significantly favorable prognostic factor for disease-free survival on univariate analysis (p = 0.0055). Conclusions: Current practice of pulmonary metastasectomy for osteosarcomas in our institution was well justified. The number of pulmonary metastases more than five and the advent of pulmonary metastases during pre- and postoperative chemotherapy seemed relevant to a worse prognosis.

    Original languageEnglish (US)
    Pages (from-to)1235-1239
    Number of pages5
    JournalEuropean Journal of Cardio-thoracic Surgery
    Volume34
    Issue number6
    DOIs
    StatePublished - Dec 1 2008

      Fingerprint

    Keywords

    • Lung
    • Metastasectomy
    • Osteosarcoma

    ASJC Scopus subject areas

    • Surgery
    • Pulmonary and Respiratory Medicine
    • Cardiology and Cardiovascular Medicine

    Cite this

    Chen, F., Miyahara, R., Bando, T., Okubo, K., Watanabe, K., Nakayama, T., Toguchida, J., & Date, H. (2008). Prognostic factors of pulmonary metastasectomy for osteosarcomas of the extremities. European Journal of Cardio-thoracic Surgery, 34(6), 1235-1239. https://doi.org/10.1016/j.ejcts.2008.07.032