Prognostic importance of dna ploidy and DNA index in stage I and II endometrioid adenocarcinoma of the endometrium

M. Pradhan, V. M. Abeler, H. E. Danielsen, B. Sandstad, C. G. Tropé, G. B. Kristensen, B. Å Risberg

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    Abstract

    Background: We evaluated the prognostic importance of DNA ploidy in stage I and II endometrioid adenocarcinoma (EAC) of the endometrium with a focus on DNA index. Patients and methods: High-resolution DNA ploidy analysis was carried out in tumor material from 937 consecutive patients with International Federation of Gynecology and Obstetrics (FIGO) stage I and II EAC of the endometrium. Results: Patients with diploid (N = 728), aneuploid tumor with DNA index ≤1.20 (N = 118), aneuploid tumors with DNA index >1.20 (N = 39) and tetraploid tumor (N = 52) had 5-year recurrence rates 8%, 14%, 20% and 12%, respectively. Patients with aneuploid tumor with DNA index >1.20 had a poorer 5-year progression-free survival (67%) and overall survival (72%) compared with the patients with aneuploid tumor with DNA index ≤1.20 (81% and 89%, respectively). Aneuploid tumors with DNA index ≤1.20 relapsed mainly in the vagina and pelvis, whereas aneuploid tumors with DNA index >1.20 relapsed predominantly outside pelvis. Conclusions: The recurrence risk for the patients with aneuploid tumor is higher than the patients with diploid tumor in EAC of the endometrium. Based on DNA index with cut-off 1.20, aneuploid tumors can be separated into two subgroups with different recurrence pattern and survival.

    Original languageEnglish (US)
    Pages (from-to)1178-1184
    Number of pages7
    JournalAnnals of Oncology
    Volume23
    Issue number5
    DOIs
    StatePublished - May 1 2012

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    Keywords

    • DNA index
    • DNA ploidy
    • EAC
    • Endometrial carcinoma
    • Image cytometry

    ASJC Scopus subject areas

    • Hematology
    • Oncology

    Cite this

    Pradhan, M., Abeler, V. M., Danielsen, H. E., Sandstad, B., Tropé, C. G., Kristensen, G. B., & Risberg, B. Å. (2012). Prognostic importance of dna ploidy and DNA index in stage I and II endometrioid adenocarcinoma of the endometrium. Annals of Oncology, 23(5), 1178-1184. https://doi.org/10.1093/annonc/mdr368