Prognostic significance of argyrophilic nucleolar organizer regions in nasopharyngeal carcinoma

M. W. Pak, K. F. To, Sing-fai Leung, C. A. Van Hasselt

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Increased expression of argyrophilic nucleolar organizer regions (AgNORs) has been identified in certain malignant tumors including nasopharyngeal carcinoma (NPC). However, its prognostic significance in NPC is uncertain and remains to be evaluated. To address this we silver-stained 63 paraffin sections of NPC cases, and examined the correlation between AgNOR count and area, calculated by the CAS 200 image analysis system, and tumor behavior, locoregional control, and survival of patients. The mean AgNOR count and area were 1.62 ± 0.31 and 3.98 ± 11.4 μm2, respectively. The AgNOR area was positively associated with T stage (r = 0.26, P = 0.04). The Mann-Whitney test confirmed no significant difference in AgNOR area and count between patients with different outcomes. Multivariate analysis using the Cox proportional hazard model showed neither AgNOR count nor area to be significant predictors of actuarial survival or disease-free survival. It is concluded that AgNOR does not have an independent and significant prognostic value in NPC. AgNOR expression may be merely a reflection of malignant phenotype as well as cellular activity but not necessarily the ultimate behavior of the tumor.

Original languageEnglish (US)
Pages (from-to)517-520
Number of pages4
JournalEuropean Archives of Oto-Rhino-Laryngology
Volume257
Issue number9
DOIs
StatePublished - Jan 1 2000

Fingerprint

Nucleolus Organizer Region
Neoplasms
Behavior Control
Survival
Nasopharyngeal carcinoma
Silver
Proportional Hazards Models
Paraffin
Disease-Free Survival
Multivariate Analysis
Phenotype

Keywords

  • Nasopharyngeal carcinoma
  • Nucleolar organizer region
  • Outcome
  • Prognosis
  • Silver-staining

ASJC Scopus subject areas

  • Otorhinolaryngology

Cite this

Prognostic significance of argyrophilic nucleolar organizer regions in nasopharyngeal carcinoma. / Pak, M. W.; To, K. F.; Leung, Sing-fai; Van Hasselt, C. A.

In: European Archives of Oto-Rhino-Laryngology, Vol. 257, No. 9, 01.01.2000, p. 517-520.

Research output: Contribution to journalArticle

Pak, M. W. ; To, K. F. ; Leung, Sing-fai ; Van Hasselt, C. A. / Prognostic significance of argyrophilic nucleolar organizer regions in nasopharyngeal carcinoma. In: European Archives of Oto-Rhino-Laryngology. 2000 ; Vol. 257, No. 9. pp. 517-520.
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