Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer

Ryoko Suzuki; Xiong Wei; Pamela K. Allen; James D. Cox; Ritsuko Komaki; Steven H. Lin

doi:10.1016/j.cllc.2018.11.013

Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer

Ryoko Suzuki
, Xiong Wei
, Pamela K. Allen
, James D. Cox
, Ritsuko Komaki
, Steven H. Lin

Research output: Contribution to journal › Article › peer-review

73 Scopus citations

Abstract

We sought markers of survival and disease control among patients treated for limited-stage small-cell lung cancer. High pretreatment total lymphocyte count was linked with superior (and high neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with inferior) median and 2-year overall survival, findings confirmed in multivariate Cox regression. Baseline lymphopenia was an indicator of poor prognosis in patients with limited-stage small-cell lung cancer.

Original language	English (US)
Pages (from-to)	117-123
Number of pages	7
Journal	Clinical Lung Cancer
Volume	20
Issue number	2
DOIs	https://doi.org/10.1016/j.cllc.2018.11.013
State	Published - Mar 2019

Keywords

Chemoradiation
Lymphopenia
Neutrophil-to-lymphocyte ratio
Overall survival
Small cell lung cancer

ASJC Scopus subject areas

Oncology
Pulmonary and Respiratory Medicine
Cancer Research

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10.1016/j.cllc.2018.11.013

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title = "Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer",

abstract = "We sought markers of survival and disease control among patients treated for limited-stage small-cell lung cancer. High pretreatment total lymphocyte count was linked with superior (and high neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with inferior) median and 2-year overall survival, findings confirmed in multivariate Cox regression. Baseline lymphopenia was an indicator of poor prognosis in patients with limited-stage small-cell lung cancer.",

keywords = "Chemoradiation, Lymphopenia, Neutrophil-to-lymphocyte ratio, Overall survival, Small cell lung cancer",

author = "Ryoko Suzuki and Xiong Wei and Allen, \{Pamela K.\} and Cox, \{James D.\} and Ritsuko Komaki and Lin, \{Steven H.\}",

note = "Publisher Copyright: {\textcopyright} 2018 Elsevier Inc.",

year = "2019",

month = mar,

doi = "10.1016/j.cllc.2018.11.013",

language = "English (US)",

volume = "20",

pages = "117--123",

journal = "Clinical Lung Cancer",

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T1 - Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer

AU - Suzuki, Ryoko

AU - Wei, Xiong

AU - Allen, Pamela K.

AU - Cox, James D.

AU - Komaki, Ritsuko

AU - Lin, Steven H.

PY - 2019/3

Y1 - 2019/3

N2 - We sought markers of survival and disease control among patients treated for limited-stage small-cell lung cancer. High pretreatment total lymphocyte count was linked with superior (and high neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with inferior) median and 2-year overall survival, findings confirmed in multivariate Cox regression. Baseline lymphopenia was an indicator of poor prognosis in patients with limited-stage small-cell lung cancer.

AB - We sought markers of survival and disease control among patients treated for limited-stage small-cell lung cancer. High pretreatment total lymphocyte count was linked with superior (and high neutrophil-to-lymphocyte and platelet-to-lymphocyte ratios with inferior) median and 2-year overall survival, findings confirmed in multivariate Cox regression. Baseline lymphopenia was an indicator of poor prognosis in patients with limited-stage small-cell lung cancer.

KW - Chemoradiation

KW - Lymphopenia

KW - Neutrophil-to-lymphocyte ratio

KW - Overall survival

KW - Small cell lung cancer

UR - https://www.scopus.com/pages/publications/85059315609

UR - https://www.scopus.com/pages/publications/85059315609#tab=citedBy

U2 - 10.1016/j.cllc.2018.11.013

DO - 10.1016/j.cllc.2018.11.013

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AN - SCOPUS:85059315609

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VL - 20

SP - 117

EP - 123

JO - Clinical Lung Cancer

JF - Clinical Lung Cancer

IS - 2

ER -

Prognostic Significance of Total Lymphocyte Count, Neutrophil-to-lymphocyte Ratio, and Platelet-to-lymphocyte Ratio in Limited-stage Small-cell Lung Cancer

Abstract

Keywords

ASJC Scopus subject areas

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