18F-氟代脱氧葡萄糖PET/CT对初诊多发性骨髓瘤患者评估预后价值分析

Translated title of the contribution: Prognostic value of 18F-FDG PET/CT in newly diagnosed multiple myeloma patients

Chaoyu Wang, Ling Wu, Chengtao Sun, Xi Wang, Bing Xia, Yizhuo Zhang

Research output: Contribution to journalArticle

Abstract

Objective: To assess the prognostic value of 18F-FDG PET/CT and its relationship with clinical features in newly diagnosed MM patients. Methods: A total of 123 patients with newly diagnosed MM in Tianjin Medical University Cancer Institute and Hospital from September 2008 to December 2017 were retrospectively reviewed. The overall survival (OS) and progression free survival (PFS) were estimated by Kaplan-Meier analysis and the distribution of OS and PFS were compared using log-rank test. Cox regression was used to identify the independent prognostic factors. Results: Of all 123 patients, there were 43 patients (35.0%) who had extramedullary diseases (EMD). Compared to the patients without EMD, the PFS (24.5 months vs 37.8 months, P<0.05) and OS (30.1 months vs 51.4 months, P<0.05) of the patients with EMD at diagnosed was significantly inferior. In multivariate analysis, β2-MG≥5.5 mg/L, age≥65, EMD on 18F-FDG PET/CT and without CR at the ending of treatments were the four factors leading to poor prognosis. According to the above four factors, the patients were regrouped into low risk, medium risk and high risk groups, the significant difference existed (P<0.01) in these groups. Conclusion: 18F-FDG PET/CT is helpful in predicting the prognosis of newly diagnosed MM patients.

Original languageChinese
Pages (from-to)301-306
Number of pages6
JournalNational Medical Journal of China
Volume99
Issue number4
DOIs
StatePublished - Jan 22 2019

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Fluorodeoxyglucose F18
Multiple Myeloma
Disease-Free Survival
Survival
Cancer Care Facilities
Kaplan-Meier Estimate
Disease Progression
Multivariate Analysis

Keywords

  • 18F-FDG PET/CT
  • Extramedullary diseases
  • Multiple myeloma
  • Prognosis

ASJC Scopus subject areas

  • Medicine(all)

Cite this

18F-氟代脱氧葡萄糖PET/CT对初诊多发性骨髓瘤患者评估预后价值分析. / Wang, Chaoyu; Wu, Ling; Sun, Chengtao; Wang, Xi; Xia, Bing; Zhang, Yizhuo.

In: National Medical Journal of China, Vol. 99, No. 4, 22.01.2019, p. 301-306.

Research output: Contribution to journalArticle

Wang, Chaoyu ; Wu, Ling ; Sun, Chengtao ; Wang, Xi ; Xia, Bing ; Zhang, Yizhuo. / 18F-氟代脱氧葡萄糖PET/CT对初诊多发性骨髓瘤患者评估预后价值分析. In: National Medical Journal of China. 2019 ; Vol. 99, No. 4. pp. 301-306.
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abstract = "Objective: To assess the prognostic value of 18F-FDG PET/CT and its relationship with clinical features in newly diagnosed MM patients. Methods: A total of 123 patients with newly diagnosed MM in Tianjin Medical University Cancer Institute and Hospital from September 2008 to December 2017 were retrospectively reviewed. The overall survival (OS) and progression free survival (PFS) were estimated by Kaplan-Meier analysis and the distribution of OS and PFS were compared using log-rank test. Cox regression was used to identify the independent prognostic factors. Results: Of all 123 patients, there were 43 patients (35.0{\%}) who had extramedullary diseases (EMD). Compared to the patients without EMD, the PFS (24.5 months vs 37.8 months, P<0.05) and OS (30.1 months vs 51.4 months, P<0.05) of the patients with EMD at diagnosed was significantly inferior. In multivariate analysis, β2-MG≥5.5 mg/L, age≥65, EMD on 18F-FDG PET/CT and without CR at the ending of treatments were the four factors leading to poor prognosis. According to the above four factors, the patients were regrouped into low risk, medium risk and high risk groups, the significant difference existed (P<0.01) in these groups. Conclusion: 18F-FDG PET/CT is helpful in predicting the prognosis of newly diagnosed MM patients.",
keywords = "18F-FDG PET/CT, Extramedullary diseases, Multiple myeloma, Prognosis",
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AU - Sun, Chengtao

AU - Wang, Xi

AU - Xia, Bing

AU - Zhang, Yizhuo

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N2 - Objective: To assess the prognostic value of 18F-FDG PET/CT and its relationship with clinical features in newly diagnosed MM patients. Methods: A total of 123 patients with newly diagnosed MM in Tianjin Medical University Cancer Institute and Hospital from September 2008 to December 2017 were retrospectively reviewed. The overall survival (OS) and progression free survival (PFS) were estimated by Kaplan-Meier analysis and the distribution of OS and PFS were compared using log-rank test. Cox regression was used to identify the independent prognostic factors. Results: Of all 123 patients, there were 43 patients (35.0%) who had extramedullary diseases (EMD). Compared to the patients without EMD, the PFS (24.5 months vs 37.8 months, P<0.05) and OS (30.1 months vs 51.4 months, P<0.05) of the patients with EMD at diagnosed was significantly inferior. In multivariate analysis, β2-MG≥5.5 mg/L, age≥65, EMD on 18F-FDG PET/CT and without CR at the ending of treatments were the four factors leading to poor prognosis. According to the above four factors, the patients were regrouped into low risk, medium risk and high risk groups, the significant difference existed (P<0.01) in these groups. Conclusion: 18F-FDG PET/CT is helpful in predicting the prognosis of newly diagnosed MM patients.

AB - Objective: To assess the prognostic value of 18F-FDG PET/CT and its relationship with clinical features in newly diagnosed MM patients. Methods: A total of 123 patients with newly diagnosed MM in Tianjin Medical University Cancer Institute and Hospital from September 2008 to December 2017 were retrospectively reviewed. The overall survival (OS) and progression free survival (PFS) were estimated by Kaplan-Meier analysis and the distribution of OS and PFS were compared using log-rank test. Cox regression was used to identify the independent prognostic factors. Results: Of all 123 patients, there were 43 patients (35.0%) who had extramedullary diseases (EMD). Compared to the patients without EMD, the PFS (24.5 months vs 37.8 months, P<0.05) and OS (30.1 months vs 51.4 months, P<0.05) of the patients with EMD at diagnosed was significantly inferior. In multivariate analysis, β2-MG≥5.5 mg/L, age≥65, EMD on 18F-FDG PET/CT and without CR at the ending of treatments were the four factors leading to poor prognosis. According to the above four factors, the patients were regrouped into low risk, medium risk and high risk groups, the significant difference existed (P<0.01) in these groups. Conclusion: 18F-FDG PET/CT is helpful in predicting the prognosis of newly diagnosed MM patients.

KW - 18F-FDG PET/CT

KW - Extramedullary diseases

KW - Multiple myeloma

KW - Prognosis

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