Progress in dendritic cell immunotherapy: Elucidating the enigma of Th-1 polarization

William K. Decker, Elizabeth J. Shpall

Research output: Contribution to journalComment/debatepeer-review

6 Scopus citations

Abstract

The goal of harnessing the immune system to effectively eradicate neoplastic disease will require the generation of robust Th-1 type immunity and durable immunological memory against the antigenic repertoire that differentiates normal self from neoplastic self. While the literature presents a very mixed picture as to the requirement of T-cell help for the generation of both primary and memory CTL responses, there appears to be a general consensus that CD4+ T-cell help will be required to generate durable responses against self cancer antigens that are devoid of foreign PAMPs and for which high-affinity T-cell clones have been deleted as a consequence of thymic selection. Here we comment briefly upon the characterization of an emerging regulatory pathway that enhances Th-1 polarization and CD8+ CTL responses by a mechanism dependent upon CD40L-mediated T-cell help. Further, we speculate that the full elucidation of this mechanism might be generally useful in answering some unresolved questions regarding the initiation of Th-1 polarized responses.

Original languageEnglish (US)
Pages (from-to)162-164
Number of pages3
JournalHuman Vaccines
Volume4
Issue number2
DOIs
StatePublished - 2008

Keywords

  • Dendritic cell
  • Immunotherapy
  • T-cell help
  • Th-1 polarization
  • Vaccination

ASJC Scopus subject areas

  • Immunology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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