Abstract
The goal of harnessing the immune system to effectively eradicate neoplastic disease will require the generation of robust Th-1 type immunity and durable immunological memory against the antigenic repertoire that differentiates normal self from neoplastic self. While the literature presents a very mixed picture as to the requirement of T-cell help for the generation of both primary and memory CTL responses, there appears to be a general consensus that CD4+ T-cell help will be required to generate durable responses against self cancer antigens that are devoid of foreign PAMPs and for which high-affinity T-cell clones have been deleted as a consequence of thymic selection. Here we comment briefly upon the characterization of an emerging regulatory pathway that enhances Th-1 polarization and CD8+ CTL responses by a mechanism dependent upon CD40L-mediated T-cell help. Further, we speculate that the full elucidation of this mechanism might be generally useful in answering some unresolved questions regarding the initiation of Th-1 polarized responses.
Original language | English (US) |
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Pages (from-to) | 162-164 |
Number of pages | 3 |
Journal | Human Vaccines |
Volume | 4 |
Issue number | 2 |
DOIs |
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State | Published - 2008 |
Keywords
- Dendritic cell
- Immunotherapy
- T-cell help
- Th-1 polarization
- Vaccination
ASJC Scopus subject areas
- Immunology
- Pharmacology, Toxicology and Pharmaceutics(all)