Progress in the chemistry of agents to modulate reproduction. Commentary on The chemical history of the Pill by Carl Djerassi

V. Craig Jordan; V. Daniel Castracane

doi:10.1016/B978-0-323-85517-4.00005-9

Progress in the chemistry of agents to modulate reproduction. Commentary on The chemical history of the Pill by Carl Djerassi

V. Craig Jordan
, V. Daniel Castracane

Breast Medical Oncology

Research output: Chapter in Book/Report/Conference proceeding › Chapter

Abstract

Nonsteroidal antiestrogens, discovered in the 1960s, were “morning after pills” in rodents that triggered ovulation in humans. The discovery of selective estrogen receptor modulation (SERM) by nonsteroidal antiestrogens, revolutionized women’s health. There are five FDA approved SERMs that switch on estrogen-like actions, such as building postmenopausal bone, lowering circulating cholesterol and increasing vaginal secretions but switch off uterine stimulation and breast cancer development, representing antiestrogen actions.

Original language	English (US)
Title of host publication	Standardizing Pharmacology
Subtitle of host publication	Assays and Hormones Discoveries in Pharmacology: Volume 2
Publisher	Elsevier
Pages	241-244
Number of pages	4
Volume	2
ISBN (Electronic)	9780323855174
DOIs	https://doi.org/10.1016/B978-0-323-85517-4.00005-9
State	Published - Jan 1 2023

Keywords

Adjuvant therapy for Breast Cancer
Carl Djerassi
SERMs
Steroid Chemistry
Tamoxifen

ASJC Scopus subject areas

General Medicine

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10.1016/B978-0-323-85517-4.00005-9

Cite this

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AB - Nonsteroidal antiestrogens, discovered in the 1960s, were “morning after pills” in rodents that triggered ovulation in humans. The discovery of selective estrogen receptor modulation (SERM) by nonsteroidal antiestrogens, revolutionized women’s health. There are five FDA approved SERMs that switch on estrogen-like actions, such as building postmenopausal bone, lowering circulating cholesterol and increasing vaginal secretions but switch off uterine stimulation and breast cancer development, representing antiestrogen actions.

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ER -

Progress in the chemistry of agents to modulate reproduction. Commentary on The chemical history of the Pill by Carl Djerassi

Abstract

Keywords

ASJC Scopus subject areas

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