TY - JOUR
T1 - Prospective assessment of patient-reported outcomes in gynecologic cancer patients before and after pelvic exenteration
AU - Armbruster, Shannon D.
AU - Sun, Charlotte C.
AU - Westin, Shannon N.
AU - Bodurka, Diane C.
AU - Ramondetta, Lois
AU - Meyer, Larissa A.
AU - Soliman, Pamela T.
N1 - Funding Information:
NIH P30CA016672 MD Anderson Cancer Center Support Grant.
Funding Information:
Andrew Sabin Family Fellowship NIH K07 CA201013.
Funding Information:
Andrew Sabin Family Fellowship NIH K07 CA201013 .
Funding Information:
Supported by the NIH/NCI under award number: 5T32 CA101642 .
Publisher Copyright:
© 2018
PY - 2018/6
Y1 - 2018/6
N2 - Objective: Pelvic exenteration (PE) is a surgical procedure associated with significant morbidity offered to select women with locally advanced or recurrent gynecologic cancers. This ongoing study examines an array of patient-reported outcomes and satisfaction with PE. Methods: Since February 2009, prospectively enrolled participants completed questionnaires evaluating body image (BIS), depression (CESD), social support (DUFSS), symptoms (MDASI), sexual function (SAQ), functional status (SF-12), quality of life (The Stoma-QOL), satisfaction with decision (SWD) and an investigator-designed survey at baseline, 6, and 12 months after PE. Mann-Whitney and Wilcoxon signed-rank tests were used to evaluate the data. Results: Fifty-four women enrolled. Median age was 56 years (31, 85). Median BMI was 30.7 kg/m2 (16.8, 54.4). The majority of patients (78%) were white. Cancer diagnoses included 41% cervix, 22% uterus, 19% vagina, 17% vulva and 2% ovary. Most surgeries were total PEs (76%). Patients were satisfied with their decision to undergo PE at 6 and 12 months. One year after exenteration, 79% of women stated they would have a PE again. Sexual pleasure decreased from baseline to 12 months after PE (p = 0.02), while sexual discomfort remained unchanged (p = 0.42). Body image worsened over time (p = 0.003). Physical functioning (SF-12) declined (p = 0.001), while mental functioning remained stable (p = 0.46). There were no significant changes in stoma-related QOL, social support, or depression scores. Conclusions: Despite a decrease in physical functioning, persistent low body image and sexual pleasure, most women were satisfied with their decision and would undergo pelvic exenteration again. This study identifies survivorship issues that should be addressed after PE.
AB - Objective: Pelvic exenteration (PE) is a surgical procedure associated with significant morbidity offered to select women with locally advanced or recurrent gynecologic cancers. This ongoing study examines an array of patient-reported outcomes and satisfaction with PE. Methods: Since February 2009, prospectively enrolled participants completed questionnaires evaluating body image (BIS), depression (CESD), social support (DUFSS), symptoms (MDASI), sexual function (SAQ), functional status (SF-12), quality of life (The Stoma-QOL), satisfaction with decision (SWD) and an investigator-designed survey at baseline, 6, and 12 months after PE. Mann-Whitney and Wilcoxon signed-rank tests were used to evaluate the data. Results: Fifty-four women enrolled. Median age was 56 years (31, 85). Median BMI was 30.7 kg/m2 (16.8, 54.4). The majority of patients (78%) were white. Cancer diagnoses included 41% cervix, 22% uterus, 19% vagina, 17% vulva and 2% ovary. Most surgeries were total PEs (76%). Patients were satisfied with their decision to undergo PE at 6 and 12 months. One year after exenteration, 79% of women stated they would have a PE again. Sexual pleasure decreased from baseline to 12 months after PE (p = 0.02), while sexual discomfort remained unchanged (p = 0.42). Body image worsened over time (p = 0.003). Physical functioning (SF-12) declined (p = 0.001), while mental functioning remained stable (p = 0.46). There were no significant changes in stoma-related QOL, social support, or depression scores. Conclusions: Despite a decrease in physical functioning, persistent low body image and sexual pleasure, most women were satisfied with their decision and would undergo pelvic exenteration again. This study identifies survivorship issues that should be addressed after PE.
KW - Patient-reported outcomes
KW - Pelvic exenteration
KW - Quality of life
KW - Survivorship
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U2 - 10.1016/j.ygyno.2018.03.054
DO - 10.1016/j.ygyno.2018.03.054
M3 - Article
C2 - 29622276
AN - SCOPUS:85044731858
SN - 0090-8258
VL - 149
SP - 484
EP - 490
JO - Gynecologic oncology
JF - Gynecologic oncology
IS - 3
ER -