TY - JOUR
T1 - Protection of cotton rats against experimental Echinococcus multilocularis infections with BCG cell walls
AU - Reuben, J. M.
AU - Tanner, C. E.
AU - Portelance, V.
PY - 1979
Y1 - 1979
N2 - Previous work has indicated that cotton rats treated with Mycobactrium bovis strain BCG are effectively protected against an infection with the metastatically proliferating metacestodes of Echinococcus multilocularis. In an attempt to induce a similar protection in the absence of tubercular granulomatous lesions, cotton rats were treated with BCG cell walls. A single injection of 150 μg of cell walls, emulsified in mineral oil-Tween-saline, 2 weeks before the inoculation of the parasite completely protected the animals against infection with E. multilocularis. This protection was correlated with an increase in the numbers of monocytes and, as judged by acid phosphatase activity, an activation of these cells. This study shows that BCG cell walls are as effective in protecting animals against E. multilocularis as the viable organism.
AB - Previous work has indicated that cotton rats treated with Mycobactrium bovis strain BCG are effectively protected against an infection with the metastatically proliferating metacestodes of Echinococcus multilocularis. In an attempt to induce a similar protection in the absence of tubercular granulomatous lesions, cotton rats were treated with BCG cell walls. A single injection of 150 μg of cell walls, emulsified in mineral oil-Tween-saline, 2 weeks before the inoculation of the parasite completely protected the animals against infection with E. multilocularis. This protection was correlated with an increase in the numbers of monocytes and, as judged by acid phosphatase activity, an activation of these cells. This study shows that BCG cell walls are as effective in protecting animals against E. multilocularis as the viable organism.
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U2 - 10.1128/iai.23.3.582-586.1979
DO - 10.1128/iai.23.3.582-586.1979
M3 - Article
C2 - 378829
AN - SCOPUS:0018404761
SN - 0019-9567
VL - 23
SP - 582
EP - 586
JO - Infection and Immunity
JF - Infection and Immunity
IS - 3
ER -