Abstract
We tested 20 protegrins against Chlamydia trachomatis serovar L2 (L2/434/Bu). Five of the protegrins had native structures; the others included nonamidated, enantiomeric, and truncated variants and peptides with <2 disulfide bonds. Antichlamydial activity resided principally in residues 5 to 15 of native protegrin PG-1, and optimal activity required both intramolecular disulfide bonds.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 4863-4866 |
| Number of pages | 4 |
| Journal | Infection and Immunity |
| Volume | 64 |
| Issue number | 11 |
| DOIs | |
| State | Published - 1996 |
ASJC Scopus subject areas
- Parasitology
- Microbiology
- Immunology
- Infectious Diseases
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