Protein complexes activate distinct caspase cascades in death receptor and stress-induced apoptosis

Shawn B. Bratton, Marion MacFarlane, Kelvin Cain, Gerald M. Cohen

Research output: Contribution to journalArticlepeer-review

298 Scopus citations

Abstract

Caspases play a central role in the execution phase of apoptosis and are responsible for many of the morphological features normally associated with this form of cell death. Caspases can activate one another and consequently can initiate specific caspase cascades. Caspases-8 and -9 appear to be the apical caspases activated in death receptor- and mitochondrial stress-induced apoptosis, respectively. The role of large protein complexes in mediating these pathways is discussed. (C) 2000 Academic Press.

Original languageEnglish (US)
Pages (from-to)27-33
Number of pages7
JournalExperimental Cell Research
Volume256
Issue number1
DOIs
StatePublished - Apr 10 2000
Externally publishedYes

Keywords

  • Apaf-1
  • Apoptosome
  • Caspases
  • DISC
  • Death domains

ASJC Scopus subject areas

  • Cell Biology

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