Abstract
Caspases play a central role in the execution phase of apoptosis and are responsible for many of the morphological features normally associated with this form of cell death. Caspases can activate one another and consequently can initiate specific caspase cascades. Caspases-8 and -9 appear to be the apical caspases activated in death receptor- and mitochondrial stress-induced apoptosis, respectively. The role of large protein complexes in mediating these pathways is discussed. (C) 2000 Academic Press.
Original language | English (US) |
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Pages (from-to) | 27-33 |
Number of pages | 7 |
Journal | Experimental Cell Research |
Volume | 256 |
Issue number | 1 |
DOIs | |
State | Published - Apr 10 2000 |
Externally published | Yes |
Keywords
- Apaf-1
- Apoptosome
- Caspases
- DISC
- Death domains
ASJC Scopus subject areas
- Cell Biology