TY - JOUR
T1 - Proton minibeams-a springboard for physics, biology and clinical creativity
AU - Dilmanian, F. Avraham
AU - Venkatesulu, Bhanu P.
AU - Sahoo, Narayan
AU - Wu, Xiaodong
AU - Nassimi, Jessica R.
AU - Herchko, Steven
AU - Lu, Jiade
AU - Dwarakanath, Bilikere S.
AU - Eley, John G.
AU - Krishnan, Sunil
PY - 2020/3/1
Y1 - 2020/3/1
N2 - Proton minibeam therapy (PMBT) is a form of spatially fractionated radiotherapy wherein broad beam radiation is replaced with segmented minibeams-either parallel, planar minibeam arrays generated by a multislit collimator or scanned pencil beams that converge laterally at depth to create a uniform dose layer at the tumor. By doing so, the spatial pattern of entrance dose is considerably modified while still maintaining tumor dose and efficacy. Recent studies using computational modeling, phantom experiments, in vitro and in vivo preclinical models, and early clinical feasibility assessments suggest that unique physical and biological attributes of PMBT can be exploited for future clinical benefit. We outline some of the guiding principle of PMBT in this concise overview of this emerging area of preclinical and clinical research inquiry.
AB - Proton minibeam therapy (PMBT) is a form of spatially fractionated radiotherapy wherein broad beam radiation is replaced with segmented minibeams-either parallel, planar minibeam arrays generated by a multislit collimator or scanned pencil beams that converge laterally at depth to create a uniform dose layer at the tumor. By doing so, the spatial pattern of entrance dose is considerably modified while still maintaining tumor dose and efficacy. Recent studies using computational modeling, phantom experiments, in vitro and in vivo preclinical models, and early clinical feasibility assessments suggest that unique physical and biological attributes of PMBT can be exploited for future clinical benefit. We outline some of the guiding principle of PMBT in this concise overview of this emerging area of preclinical and clinical research inquiry.
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U2 - 10.1259/bjr.20190332
DO - 10.1259/bjr.20190332
M3 - Article
C2 - 31944824
SN - 0007-1285
VL - 93
JO - The British journal of radiology
JF - The British journal of radiology
IS - 1107
ER -