Psychoneuroimmunology and Cancer: Biobehavioral Influences on Tumor Progression

Susan K. Lutgendorf, Erin S. Costanzo, Anil K. Sood

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Scopus citations

Abstract

This chapter examines the role of psychosocial factors and stress-related neuroendocrine hormones in cancer progression. The neuroendocrine stress response appears to play a key role in modulating physiological pathways relevant to cancer progression. These include tumor angiogenesis, invasion, anoikis, inflammation, the cellular immune response, and various cell-signaling pathways. These stress-response pathways also potentially interact with cancer treatments. Bidirectional influences of tumor-derived cytokines and other molecules on the hypothalamic pituitary adrenal (HPA) axis and CNS processes are also discussed along with implications for disease progression and survival. These mechanisms point to emerging possibilities for psychosocial, pharmacological, and integrative medicine interventions that have the potential to alter stress-response signaling pathways in cancer.

Original languageEnglish (US)
Title of host publicationThe Oxford Handbook of Psychoneuroimmunology
PublisherOxford University Press
ISBN (Electronic)9780199971190
ISBN (Print)9780195394399
DOIs
StatePublished - Nov 21 2012

Keywords

  • Angiogenesis
  • Cancer
  • Depression
  • Immunity
  • Inflammation
  • Invasion
  • Psychoneuroimmunology
  • Stress

ASJC Scopus subject areas

  • General Psychology

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