TY - JOUR
T1 - Quantitative Dual-Energy CT Image Guidance for Thermochemical Ablation
T2 - In Vivo Results in the Rabbit VX2 Model
AU - Thompson, Emily A.
AU - Fowlkes, Natalie W.
AU - Jacobsen, Megan C.
AU - Layman, Rick R.
AU - Cressman, Erik N.K.
N1 - Funding Information:
This research was supported by the SIR Foundation Allied Scientist Training Grant, R01CA201127, and the John S. Dunn Foundation.
Funding Information:
This research was supported by the SIR Foundation Allied Scientist Training Grant, R01CA201127, and the John S. Dunn Foundation. E.A.T. reports a Society of Interventional Radiology (SIR) Foundation Allied Scientist Training Grant, a Cancer Prevention and Research Institute of Texas Graduate Scholar Award (RP210028), and a grant (R01CA201127) from the National Institutes of Health. R.R.L. reports receiving the following grants: NIH S10 1S10OD028621-01A1, Cancer Prevention and Research Institute of Texas RP220366, USDA Small Business Innovation Research NIFA Phase II, MDACC Institutional Research Grant, NIH 5R01HL141831-04, NASA 80NSSC18K1639, T32 FP 13417, and SIR FP10908; speaking honoraria from American College of Radiology Regional Chapter; advisory board participation in GE Healthcare; leadership role as American Association of Physicists in Medicine Task Group Co-Chair; and receipt of research materials from Siemens Healthineers and MARS Bioimaging Ltd. E.N.K.C. reports leadership roles in the SIR Annual Meeting Committee and Global Embolization and Technologies Meeting Research Committee. None of the other authors have identified a conflict of interest. From the 2022 SIR Annual Scientific Meeting (SIR Foundation Allied Scientist Training Grant presentation, “Multi-modal imaging for characterization of thermochemical ablation”) and the 2022 Radiological Society of North America Scientific Assembly and Annual Meeting (Abstract No. 2022-SP-10766-RSNA, “Quantitative image-guided intervention for hepatocellular carcinoma: DECT for in vivo application of thermochemical ablation”).
Funding Information:
E.A.T. reports a Society of Interventional Radiology (SIR) Foundation Allied Scientist Training Grant, a Cancer Prevention and Research Institute of Texas Graduate Scholar Award (RP210028), and a grant (R01CA201127) from the National Institutes of Health. R.R.L. reports receiving the following grants: NIH S10 1S10OD028621-01A1, Cancer Prevention and Research Institute of Texas RP220366, USDA Small Business Innovation Research NIFA Phase II, MDACC Institutional Research Grant, NIH 5R01HL141831-04, NASA 80NSSC18K1639, T32 FP 13417, and SIR FP10908; speaking honoraria from American College of Radiology Regional Chapter; advisory board participation in GE Healthcare; leadership role as American Association of Physicists in Medicine Task Group Co-Chair; and receipt of research materials from Siemens Healthineers and MARS Bioimaging Ltd. E.N.K.C. reports leadership roles in the SIR Annual Meeting Committee and Global Embolization and Technologies Meeting Research Committee. None of the other authors have identified a conflict of interest.
Publisher Copyright:
© 2022 SIR
PY - 2023/5
Y1 - 2023/5
N2 - Purpose: To evaluate the feasibility of using dual-energy computed tomography (CT) and theranostic cesium hydroxide (CsOH) for image guidance of thermochemical ablation (TCA) in a rabbit VX2 tumor model. Materials and Methods: In vivo experiments were performed on New Zealand white rabbits, where VX2 tumor fragments (0.3 mL) were inoculated into the right and left flanks (n = 16 rabbits, 32 tumors). Catheters were placed in the approximate center of 1- to 2-cm diameter tumors under ultrasound guidance. TCA was delivered in 1 of 3 treatment groups: untreated control, 5-M TCA, or 10-M TCA. The TCA base reagent was doped with 250-mM CsOH. Dual-energy CT was performed before and after TCA. Cesium (CS)-specific images were postprocessed on the basis of previous phantom calibrations to determine Cs concentration. Line profiles were drawn through the ablation center. Twenty-four hours after TCA, subjects were euthanized, and the resulting damage was evaluated with histopathology. Results: Cs was detected in 100% of treated tumors (n = 21). Line profiles indicated highest concentrations at the injection site and decreased concentrations at the tumor margins, with no Cs detected beyond the ablation zone. The maximum detected Cs concentration ranged from 14.39 to 137.33 mM. A dose-dependent trend in tissue necrosis was demonstrated between the 10-M TCA and 5-M TCA treatment groups (P = .0005) and untreated controls (P = .0089). Conclusions: Dual-energy CT provided image guidance for delivery, localization, and quantification of TCA in the rabbit VX2 model.
AB - Purpose: To evaluate the feasibility of using dual-energy computed tomography (CT) and theranostic cesium hydroxide (CsOH) for image guidance of thermochemical ablation (TCA) in a rabbit VX2 tumor model. Materials and Methods: In vivo experiments were performed on New Zealand white rabbits, where VX2 tumor fragments (0.3 mL) were inoculated into the right and left flanks (n = 16 rabbits, 32 tumors). Catheters were placed in the approximate center of 1- to 2-cm diameter tumors under ultrasound guidance. TCA was delivered in 1 of 3 treatment groups: untreated control, 5-M TCA, or 10-M TCA. The TCA base reagent was doped with 250-mM CsOH. Dual-energy CT was performed before and after TCA. Cesium (CS)-specific images were postprocessed on the basis of previous phantom calibrations to determine Cs concentration. Line profiles were drawn through the ablation center. Twenty-four hours after TCA, subjects were euthanized, and the resulting damage was evaluated with histopathology. Results: Cs was detected in 100% of treated tumors (n = 21). Line profiles indicated highest concentrations at the injection site and decreased concentrations at the tumor margins, with no Cs detected beyond the ablation zone. The maximum detected Cs concentration ranged from 14.39 to 137.33 mM. A dose-dependent trend in tissue necrosis was demonstrated between the 10-M TCA and 5-M TCA treatment groups (P = .0005) and untreated controls (P = .0089). Conclusions: Dual-energy CT provided image guidance for delivery, localization, and quantification of TCA in the rabbit VX2 model.
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U2 - 10.1016/j.jvir.2022.12.026
DO - 10.1016/j.jvir.2022.12.026
M3 - Article
C2 - 36539151
AN - SCOPUS:85146456980
SN - 1051-0443
VL - 34
SP - 782
EP - 789
JO - Journal of Vascular and Interventional Radiology
JF - Journal of Vascular and Interventional Radiology
IS - 5
ER -