Quantitative measurement of post-irradiation neck fibrosis based on the young modulus: Description of a new method and clinical results

Sing Fai Leung, Yongping Zheng, Charles Y K Choi, Suzanne S S Mak, Samuel K W Chiu, Benny Zee, Arthur F T Mak

Research output: Contribution to journalArticle

  • 39 Citations

Abstract

LanguageEnglish (US)
Pages656-662
Number of pages7
JournalCancer
Volume95
Issue number3
DOIs
StatePublished - Aug 1 2002

Fingerprint

Elastic Modulus
Fibrosis
Neck
Palpation
Radiotherapy
Hand
Radiation
Head
Carcinoma

Keywords

  • Fibrosis
  • Indentation
  • Neck
  • Radiation therapy
  • Ultrasound

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Leung, S. F., Zheng, Y., Choi, C. Y. K., Mak, S. S. S., Chiu, S. K. W., Zee, B., & Mak, A. F. T. (2002). Quantitative measurement of post-irradiation neck fibrosis based on the young modulus: Description of a new method and clinical results. Cancer, 95(3), 656-662. https://doi.org/10.1002/cncr.10700

Quantitative measurement of post-irradiation neck fibrosis based on the young modulus : Description of a new method and clinical results. / Leung, Sing Fai; Zheng, Yongping; Choi, Charles Y K; Mak, Suzanne S S; Chiu, Samuel K W; Zee, Benny; Mak, Arthur F T.

In: Cancer, Vol. 95, No. 3, 01.08.2002, p. 656-662.

Research output: Contribution to journalArticle

Leung, Sing Fai ; Zheng, Yongping ; Choi, Charles Y K ; Mak, Suzanne S S ; Chiu, Samuel K W ; Zee, Benny ; Mak, Arthur F T. / Quantitative measurement of post-irradiation neck fibrosis based on the young modulus : Description of a new method and clinical results. In: Cancer. 2002 ; Vol. 95, No. 3. pp. 656-662.
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title = "Quantitative measurement of post-irradiation neck fibrosis based on the young modulus: Description of a new method and clinical results",
abstract = "BACKGROUND. Postirradiation fibrosis is one of the most common late effects of radiation therapy for patients with head and neck carcinoma. An objective and quantitative method for its measurement is much desired, but the criteria currently used to score fibrosis are mostly semiquantitative and partially subjective. METHODS. The Young Modulus (YM) is a physical parameter that characterizes the deformability of material to stress. The authors measured the YM in soft tissues of the neck, at defined reference points, using an ultrasound probe and computer algorithm that quantified the indentation (deformation) on tissue due to a measured, applied force. One hundred five patients who had received previous radiation therapy to the entire neck were assessed, and the results were compared with the hand palpation scores and with a functional parameter represented by the range of neck rotation, and all results were correlated with symptoms. RESULTS. The YM was obtained successfully in all patients examined. It had a significant positive correlation with the palpation score and a significant negative correlation with the range of neck rotation. The YM was significantly higher on the side of the neck that received a boost dose of radiation, although the corresponding palpation scores were similar. The results of all three measurement methods were correlated with symptoms. CONCLUSIONS. Postirradiation neck fibrosis can be measured in absolute units based on the YM. The results showed a significant correlation with hand palpation scores, with restriction of neck rotation, and with symptoms. Compared with the palpation method, the YM is more quantitative, objective, focused on small subregions, and better discriminates regions subject to differential radiation dose levels. Its inclusion in the Analytic category of the Late Effects of Normal Tissues-SOMA system should be considered to facilitate comparative studies.",
keywords = "Fibrosis, Indentation, Neck, Radiation therapy, Ultrasound",
author = "Leung, {Sing Fai} and Yongping Zheng and Choi, {Charles Y K} and Mak, {Suzanne S S} and Chiu, {Samuel K W} and Benny Zee and Mak, {Arthur F T}",
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T1 - Quantitative measurement of post-irradiation neck fibrosis based on the young modulus

T2 - Cancer

AU - Leung, Sing Fai

AU - Zheng, Yongping

AU - Choi, Charles Y K

AU - Mak, Suzanne S S

AU - Chiu, Samuel K W

AU - Zee, Benny

AU - Mak, Arthur F T

PY - 2002/8/1

Y1 - 2002/8/1

N2 - BACKGROUND. Postirradiation fibrosis is one of the most common late effects of radiation therapy for patients with head and neck carcinoma. An objective and quantitative method for its measurement is much desired, but the criteria currently used to score fibrosis are mostly semiquantitative and partially subjective. METHODS. The Young Modulus (YM) is a physical parameter that characterizes the deformability of material to stress. The authors measured the YM in soft tissues of the neck, at defined reference points, using an ultrasound probe and computer algorithm that quantified the indentation (deformation) on tissue due to a measured, applied force. One hundred five patients who had received previous radiation therapy to the entire neck were assessed, and the results were compared with the hand palpation scores and with a functional parameter represented by the range of neck rotation, and all results were correlated with symptoms. RESULTS. The YM was obtained successfully in all patients examined. It had a significant positive correlation with the palpation score and a significant negative correlation with the range of neck rotation. The YM was significantly higher on the side of the neck that received a boost dose of radiation, although the corresponding palpation scores were similar. The results of all three measurement methods were correlated with symptoms. CONCLUSIONS. Postirradiation neck fibrosis can be measured in absolute units based on the YM. The results showed a significant correlation with hand palpation scores, with restriction of neck rotation, and with symptoms. Compared with the palpation method, the YM is more quantitative, objective, focused on small subregions, and better discriminates regions subject to differential radiation dose levels. Its inclusion in the Analytic category of the Late Effects of Normal Tissues-SOMA system should be considered to facilitate comparative studies.

AB - BACKGROUND. Postirradiation fibrosis is one of the most common late effects of radiation therapy for patients with head and neck carcinoma. An objective and quantitative method for its measurement is much desired, but the criteria currently used to score fibrosis are mostly semiquantitative and partially subjective. METHODS. The Young Modulus (YM) is a physical parameter that characterizes the deformability of material to stress. The authors measured the YM in soft tissues of the neck, at defined reference points, using an ultrasound probe and computer algorithm that quantified the indentation (deformation) on tissue due to a measured, applied force. One hundred five patients who had received previous radiation therapy to the entire neck were assessed, and the results were compared with the hand palpation scores and with a functional parameter represented by the range of neck rotation, and all results were correlated with symptoms. RESULTS. The YM was obtained successfully in all patients examined. It had a significant positive correlation with the palpation score and a significant negative correlation with the range of neck rotation. The YM was significantly higher on the side of the neck that received a boost dose of radiation, although the corresponding palpation scores were similar. The results of all three measurement methods were correlated with symptoms. CONCLUSIONS. Postirradiation neck fibrosis can be measured in absolute units based on the YM. The results showed a significant correlation with hand palpation scores, with restriction of neck rotation, and with symptoms. Compared with the palpation method, the YM is more quantitative, objective, focused on small subregions, and better discriminates regions subject to differential radiation dose levels. Its inclusion in the Analytic category of the Late Effects of Normal Tissues-SOMA system should be considered to facilitate comparative studies.

KW - Fibrosis

KW - Indentation

KW - Neck

KW - Radiation therapy

KW - Ultrasound

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U2 - 10.1002/cncr.10700

DO - 10.1002/cncr.10700

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VL - 95

SP - 656

EP - 662

JO - Cancer

JF - Cancer

SN - 0008-543X

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