TY - JOUR
T1 - Radiation-Induced Endothelial Vascular Injury
T2 - A Review of Possible Mechanisms
AU - Venkatesulu, Bhanu Prasad
AU - Mahadevan, Lakshmi Shree
AU - Aliru, Maureen L.
AU - Yang, Xi
AU - Bodd, Monica Himaani
AU - Singh, Pankaj K.
AU - Yusuf, Syed Wamique
AU - Abe, Jun ichi
AU - Krishnan, Sunil
N1 - Funding Information:
Supported in part by National Institutes of Health grants HL-130193, HL-123346, and HL-118462 to Dr. Abe; and grant P30 CA16672 to the University of Texas MD Anderson Cancer Center. Dr. Krishnan holds the John E. and Dorothy J. Harris Endowed Professorship. All authors have reported that they have no relationships with industry relevant to the contents of this paper to disclose.
Publisher Copyright:
© 2018
PY - 2018/8
Y1 - 2018/8
N2 - In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. Increased levels of proinflammatory cytokines in the blood of long-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury.
AB - In radiation therapy for cancer, the therapeutic ratio represents an optimal balance between tumor control and normal tissue complications. As improvements in the therapeutic arsenal against cancer extend longevity, the importance of late effects of radiation increases, particularly those caused by vascular endothelial injury. Radiation both initiates and accelerates atherosclerosis, leading to vascular events like stroke, coronary artery disease, and peripheral artery disease. Increased levels of proinflammatory cytokines in the blood of long-term survivors of the atomic bomb suggest that radiation evokes a systemic inflammatory state responsible for chronic vascular side effects. In this review, the authors offer an overview of potential mechanisms implicated in radiation-induced vascular injury.
KW - angiogenesis
KW - apoptosis
KW - cytokines
KW - senescence
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U2 - 10.1016/j.jacbts.2018.01.014
DO - 10.1016/j.jacbts.2018.01.014
M3 - Review article
C2 - 30175280
AN - SCOPUS:85053834493
SN - 2452-302X
VL - 3
SP - 563
EP - 572
JO - JACC: Basic to Translational Science
JF - JACC: Basic to Translational Science
IS - 4
ER -