Radiation-Induced Vascular Disease—A State-of-the-Art Review

Eric H. Yang; Konstantinos Marmagkiolis; Dinu V. Balanescu; Abdul Hakeem; Teodora Donisan; William Finch; Renu Virmani; Joerg Herrman; Mehmet Cilingiroglu; Cindy L. Grines; Konstantinos Toutouzas; Cezar Iliescu

doi:10.3389/fcvm.2021.652761

Radiation-Induced Vascular Disease—A State-of-the-Art Review

Eric H. Yang, Konstantinos Marmagkiolis, Dinu V. Balanescu, Abdul Hakeem, Teodora Donisan, William Finch, Renu Virmani, Joerg Herrman, Mehmet Cilingiroglu, Cindy L. Grines, Konstantinos Toutouzas, Cezar Iliescu

Cardiology

Research output: Contribution to journal › Review article › peer-review

37 Scopus citations

Abstract

Since the 1990s, there has been a steady increase in the number of cancer survivors to an estimated 17 million in 2019 in the US alone. Radiation therapy today is applied to a variety of malignancies and over 50% of cancer patients. The effects of ionizing radiation on cardiac structure and function, so-called radiation-induced heart disease (RIHD), have been extensively studied. We review the available published data on the mechanisms and manifestations of RIHD, with a focus on vascular disease, as well as proposed strategies for its prevention, screening, diagnosis, and management.

Original language	English (US)
Article number	652761
Journal	Frontiers in Cardiovascular Medicine
Volume	8
DOIs	https://doi.org/10.3389/fcvm.2021.652761
State	Published - Mar 30 2021

Keywords

cancer
cardio-oncology
coronary artery disease
peripheral arterial disease
radiation therapy

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.3389/fcvm.2021.652761

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abstract = "Since the 1990s, there has been a steady increase in the number of cancer survivors to an estimated 17 million in 2019 in the US alone. Radiation therapy today is applied to a variety of malignancies and over 50% of cancer patients. The effects of ionizing radiation on cardiac structure and function, so-called radiation-induced heart disease (RIHD), have been extensively studied. We review the available published data on the mechanisms and manifestations of RIHD, with a focus on vascular disease, as well as proposed strategies for its prevention, screening, diagnosis, and management.",

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AU - Hakeem, Abdul

AU - Donisan, Teodora

AU - Finch, William

AU - Virmani, Renu

AU - Herrman, Joerg

AU - Cilingiroglu, Mehmet

AU - Grines, Cindy L.

AU - Toutouzas, Konstantinos

AU - Iliescu, Cezar

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KW - cardio-oncology

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Radiation-Induced Vascular Disease—A State-of-the-Art Review

Abstract

Keywords

ASJC Scopus subject areas

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