TY - JOUR
T1 - Radiation Pneumonitis
T2 - Local Dose Versus [18F]-Fluorodeoxyglucose Uptake Response in Irradiated Lung
AU - Guerrero, Thomas
AU - Johnson, Valen
AU - Hart, Justin
AU - Pan, Tinsu
AU - Khan, Meena
AU - Luo, Dershan
AU - Liao, Zhongxing
AU - Ajani, Jaffer
AU - Stevens, Craig
AU - Komaki, Ritsuko
N1 - Funding Information:
Supported by funding from the University of Texas M.D. Anderson Cancer Center Multi-Disciplinary Research Project titled “Lung Injury Following Cancer Treatment” and through the University of Texas M.D. Anderson Cancer Center’s Physician Scientist Program.
PY - 2007/7/15
Y1 - 2007/7/15
N2 - Purpose: To quantify the relationship between the local radiation dose received and the posttreatment positron emission tomography/computed tomography (PET/CT) [18F]2-fluoro-2-deoxyglucose (FDG) uptake in the lung. Methods and Materials: The data from 36 patients treated for esophageal cancer with thoracic radiotherapy who underwent restaging PET/CT imaging between 4 and 12 weeks after radiotherapy completion were evaluated. Their treatment planning CT was registered with the restaging PET/CT. Using histogram analysis, the voxel average FDG-PET uptake vs. radiation dose was obtained for each case. Hierarchical linear regression models for each patient were applied to study the variation in the linear trends between cases. Deviation of the dose-response curve from a linear model was tested. Results: The median time between radiotherapy completion and FDG-PET imaging was 40 days (range, 26-70 days). The median of the mean standard uptake value in the lung that received 0-5 Gy was 0.63 (range, 0.36-1.27), 5-10 Gy was 0.77 (range, 0.40-1.35), 10-20 Gy was 0.80 (range, 0.40-1.72), and >20 Gy was 1.08 (range, 0.44-2.63). A hierarchical linear regression model of the radiation dose and normalized FDG uptake per case found an adequate fit with the linear model, and the addition of quadratic and logarithmic functions did not improve the fit. The 36 cases had a posterior mean of slopes range of 0.0048-0.069. Conclusion: The regional dose vs. radiation pneumonitis response was evaluated with FDG-PET/CT imaging. Statistical modeling found a linear relationship. The slope of this relationship varied over an order of magnitude, reflecting the range of the underlying biological response to radiation among the study population.
AB - Purpose: To quantify the relationship between the local radiation dose received and the posttreatment positron emission tomography/computed tomography (PET/CT) [18F]2-fluoro-2-deoxyglucose (FDG) uptake in the lung. Methods and Materials: The data from 36 patients treated for esophageal cancer with thoracic radiotherapy who underwent restaging PET/CT imaging between 4 and 12 weeks after radiotherapy completion were evaluated. Their treatment planning CT was registered with the restaging PET/CT. Using histogram analysis, the voxel average FDG-PET uptake vs. radiation dose was obtained for each case. Hierarchical linear regression models for each patient were applied to study the variation in the linear trends between cases. Deviation of the dose-response curve from a linear model was tested. Results: The median time between radiotherapy completion and FDG-PET imaging was 40 days (range, 26-70 days). The median of the mean standard uptake value in the lung that received 0-5 Gy was 0.63 (range, 0.36-1.27), 5-10 Gy was 0.77 (range, 0.40-1.35), 10-20 Gy was 0.80 (range, 0.40-1.72), and >20 Gy was 1.08 (range, 0.44-2.63). A hierarchical linear regression model of the radiation dose and normalized FDG uptake per case found an adequate fit with the linear model, and the addition of quadratic and logarithmic functions did not improve the fit. The 36 cases had a posterior mean of slopes range of 0.0048-0.069. Conclusion: The regional dose vs. radiation pneumonitis response was evaluated with FDG-PET/CT imaging. Statistical modeling found a linear relationship. The slope of this relationship varied over an order of magnitude, reflecting the range of the underlying biological response to radiation among the study population.
KW - Computed tomography
KW - Positron emission tomography
KW - Pulmonary injury
KW - Radiation pneumonitis
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U2 - 10.1016/j.ijrobp.2007.01.031
DO - 10.1016/j.ijrobp.2007.01.031
M3 - Article
C2 - 17398033
AN - SCOPUS:34447266435
SN - 0360-3016
VL - 68
SP - 1030
EP - 1035
JO - International Journal of Radiation Oncology Biology Physics
JF - International Journal of Radiation Oncology Biology Physics
IS - 4
ER -