TY - JOUR
T1 - Radiofrequency Ablation of Hepatic Tumor
T2 - Subjective Assessment of the Perilesional Vascular Network on Contrast-Enhanced Computed Tomography before and after Ablation Can Reliably Predict the Risk of Local Recurrence
AU - Yedururi, Sireesha
AU - Terpenning, Silanath
AU - Gupta, Sanjay
AU - Fox, Patricia
AU - Martin, Sooyoung Shin
AU - Conrad, Claudius
AU - Loyer, Evelyne M.
N1 - Publisher Copyright:
© 2017 Wolters Kluwer Health, Inc. All rights reserved.
PY - 2017/7/1
Y1 - 2017/7/1
N2 - Objective To determine whether simple, subjective analysis of the perilesional vascular network can predict the risk of local recurrence after radiofrequency ablation (RFA) of liver malignancies on contrast-enhanced computed tomography (CECT). Methods Contrast-enhanced computed tomography's 103 patients (59 men and 44 women; mean age, 63 years (range, 31-84 years) with 134 lesions who underwent RFA between 2000 and 2010 were retrospectively analyzed. The primary tumors include colorectal carcinoma (58 patients), hepatocellular carcinoma (n = 13), breast carcinoma (n = 8), neuroendocrine tumor (n = 5), and others (n = 19). Three blinded radiologists independently reviewed the CECT (a triple phase liver protocol for hypervascular tumors and a single phase for the hypovascular tumors) before and 6 weeks after RFA and subjectively estimated the width of the ablative margin on a 3-point scale (optimal, 1; suboptimal, 2; and residual tumor, 3). Local recurrence was determined on follow-up CECT. Results The consensus score was 1 in 94, 2 in 28, and 3 in 12 lesions. κ among readers was 0.75. Local recurrence occurred in 3 lesions with a score of 1 and 12 lesions with a score of 2. The consensus score was a significant univariate predictor of local recurrence. Conclusions Subjective estimation of the width of ablative margin can reliably predict the risk of local recurrence.
AB - Objective To determine whether simple, subjective analysis of the perilesional vascular network can predict the risk of local recurrence after radiofrequency ablation (RFA) of liver malignancies on contrast-enhanced computed tomography (CECT). Methods Contrast-enhanced computed tomography's 103 patients (59 men and 44 women; mean age, 63 years (range, 31-84 years) with 134 lesions who underwent RFA between 2000 and 2010 were retrospectively analyzed. The primary tumors include colorectal carcinoma (58 patients), hepatocellular carcinoma (n = 13), breast carcinoma (n = 8), neuroendocrine tumor (n = 5), and others (n = 19). Three blinded radiologists independently reviewed the CECT (a triple phase liver protocol for hypervascular tumors and a single phase for the hypovascular tumors) before and 6 weeks after RFA and subjectively estimated the width of the ablative margin on a 3-point scale (optimal, 1; suboptimal, 2; and residual tumor, 3). Local recurrence was determined on follow-up CECT. Results The consensus score was 1 in 94, 2 in 28, and 3 in 12 lesions. κ among readers was 0.75. Local recurrence occurred in 3 lesions with a score of 1 and 12 lesions with a score of 2. The consensus score was a significant univariate predictor of local recurrence. Conclusions Subjective estimation of the width of ablative margin can reliably predict the risk of local recurrence.
KW - ablation margin
KW - computed tomography
KW - liver
KW - primary and metastatic liver lesions
KW - radiofrequency ablation
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U2 - 10.1097/RCT.0000000000000562
DO - 10.1097/RCT.0000000000000562
M3 - Article
C2 - 28722702
AN - SCOPUS:85026301985
SN - 0363-8715
VL - 41
SP - 607
EP - 613
JO - Journal of computer assisted tomography
JF - Journal of computer assisted tomography
IS - 4
ER -