Randomized trial of Tibetan yoga in patients with breast cancer undergoing chemotherapy

Alejandro Chaoul; Kathrin Milbury; Amy Spelman; Karen Basen-Engquist; Martica H. Hall; Qi Wei; Ya Chen Tina Shih; Banu Arun; Vicente Valero; George H. Perkins; Gildy V. Babiera; Tenzin Wangyal; Rosalinda Engle; Carol A. Harrison; Yisheng Li; Lorenzo Cohen

doi:10.1002/cncr.30938

Randomized trial of Tibetan yoga in patients with breast cancer undergoing chemotherapy

Alejandro Chaoul, Kathrin Milbury, Amy Spelman, Karen Basen-Engquist, Martica H. Hall, Qi Wei, Ya Chen Tina Shih, Banu Arun, Vicente Valero, George H. Perkins, Gildy V. Babiera, Tenzin Wangyal, Rosalinda Engle, Carol A. Harrison, Yisheng Li, Lorenzo Cohen

Research output: Contribution to journal › Article › peer-review

62 Scopus citations

Abstract

BACKGROUND: The current randomized trial examined the effects of a Tibetan yoga program (TYP) versus a stretching program (STP) and usual care (UC) on sleep and fatigue in women with breast cancer who were undergoing chemotherapy. METHODS: Women with stage (American Joint Committee on Cancer (AJCC) TNM) I to III breast cancer who were undergoing chemotherapy were randomized to TYP (74 women), STP (68 women), or UC (85 women). Participants in the TYP and STP groups participated in 4 sessions during chemotherapy, followed by 3 booster sessions over the subsequent 6 months, and were encouraged to practice at home. Self-report measures of sleep disturbances (Pittsburgh Sleep Quality Index), fatigue (Brief Fatigue Inventory), and actigraphy were collected at baseline; 1 week after treatment; and at 3, 6, and 12 months. RESULTS: There were no group differences noted in total sleep disturbances or fatigue levels over time. However, patients in the TYP group reported fewer daily disturbances 1 week after treatment compared with those in the STP (difference, -0.43; 95% confidence interval [95% CI], -0.82 to -0.04 [P =.03]) and UC (difference, -0.41; 95% CI, -0.77 to -0.05 [P =.02]) groups. Group differences at the other time points were maintained for TYP versus STP. Actigraphy data revealed greater minutes awake after sleep onset for patients in the STP group 1 week after treatment versus those in the TYP (difference, 15.36; 95% CI, 7.25-23.48 [P =.0003]) and UC (difference, 14.48; 95% CI, 7.09-21.87 [P =.0002]) groups. Patients in the TYP group who practiced at least 2 times a week during follow-up reported better Pittsburgh Sleep Quality Index and actigraphy outcomes at 3 months and 6 months after treatment compared with those who did not and better outcomes compared with those in the UC group. CONCLUSIONS: Participating in TYP during chemotherapy resulted in modest short-term benefits in sleep quality, with long-term benefits emerging over time for those who practiced TYP at least 2 times a week. Cancer 2018;124:36-45.

Original language	English (US)
Pages (from-to)	36-45
Number of pages	10
Journal	Cancer
Volume	124
Issue number	1
DOIs	https://doi.org/10.1002/cncr.30938
State	Published - Jan 1 2018

Keywords

Tibetan yoga
breast cancer
chemotherapy
patients
sleep quality

ASJC Scopus subject areas

Oncology
Cancer Research

MD Anderson CCSG core facilities

Biostatistics Resource Group

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10.1002/cncr.30938

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@article{2c04706ab94044fe802567b6b323dc08,

title = "Randomized trial of Tibetan yoga in patients with breast cancer undergoing chemotherapy",

abstract = "BACKGROUND: The current randomized trial examined the effects of a Tibetan yoga program (TYP) versus a stretching program (STP) and usual care (UC) on sleep and fatigue in women with breast cancer who were undergoing chemotherapy. METHODS: Women with stage (American Joint Committee on Cancer (AJCC) TNM) I to III breast cancer who were undergoing chemotherapy were randomized to TYP (74 women), STP (68 women), or UC (85 women). Participants in the TYP and STP groups participated in 4 sessions during chemotherapy, followed by 3 booster sessions over the subsequent 6 months, and were encouraged to practice at home. Self-report measures of sleep disturbances (Pittsburgh Sleep Quality Index), fatigue (Brief Fatigue Inventory), and actigraphy were collected at baseline; 1 week after treatment; and at 3, 6, and 12 months. RESULTS: There were no group differences noted in total sleep disturbances or fatigue levels over time. However, patients in the TYP group reported fewer daily disturbances 1 week after treatment compared with those in the STP (difference, -0.43; 95% confidence interval [95% CI], -0.82 to -0.04 [P =.03]) and UC (difference, -0.41; 95% CI, -0.77 to -0.05 [P =.02]) groups. Group differences at the other time points were maintained for TYP versus STP. Actigraphy data revealed greater minutes awake after sleep onset for patients in the STP group 1 week after treatment versus those in the TYP (difference, 15.36; 95% CI, 7.25-23.48 [P =.0003]) and UC (difference, 14.48; 95% CI, 7.09-21.87 [P =.0002]) groups. Patients in the TYP group who practiced at least 2 times a week during follow-up reported better Pittsburgh Sleep Quality Index and actigraphy outcomes at 3 months and 6 months after treatment compared with those who did not and better outcomes compared with those in the UC group. CONCLUSIONS: Participating in TYP during chemotherapy resulted in modest short-term benefits in sleep quality, with long-term benefits emerging over time for those who practiced TYP at least 2 times a week. Cancer 2018;124:36-45.",

keywords = "Tibetan yoga, breast cancer, chemotherapy, patients, sleep quality",

author = "Alejandro Chaoul and Kathrin Milbury and Amy Spelman and Karen Basen-Engquist and Hall, {Martica H.} and Qi Wei and Shih, {Ya Chen Tina} and Banu Arun and Vicente Valero and Perkins, {George H.} and Babiera, {Gildy V.} and Tenzin Wangyal and Rosalinda Engle and Harrison, {Carol A.} and Yisheng Li and Lorenzo Cohen",

note = "Publisher Copyright: {\textcopyright} 2017 American Cancer Society",

year = "2018",

month = jan,

day = "1",

doi = "10.1002/cncr.30938",

language = "English (US)",

volume = "124",

pages = "36--45",

journal = "Cancer",

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publisher = "John Wiley and Sons Inc.",

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TY - JOUR

T1 - Randomized trial of Tibetan yoga in patients with breast cancer undergoing chemotherapy

AU - Chaoul, Alejandro

AU - Milbury, Kathrin

AU - Spelman, Amy

AU - Basen-Engquist, Karen

AU - Hall, Martica H.

AU - Wei, Qi

AU - Shih, Ya Chen Tina

AU - Arun, Banu

AU - Valero, Vicente

AU - Perkins, George H.

AU - Babiera, Gildy V.

AU - Wangyal, Tenzin

AU - Engle, Rosalinda

AU - Harrison, Carol A.

AU - Li, Yisheng

AU - Cohen, Lorenzo

PY - 2018/1/1

Y1 - 2018/1/1

N2 - BACKGROUND: The current randomized trial examined the effects of a Tibetan yoga program (TYP) versus a stretching program (STP) and usual care (UC) on sleep and fatigue in women with breast cancer who were undergoing chemotherapy. METHODS: Women with stage (American Joint Committee on Cancer (AJCC) TNM) I to III breast cancer who were undergoing chemotherapy were randomized to TYP (74 women), STP (68 women), or UC (85 women). Participants in the TYP and STP groups participated in 4 sessions during chemotherapy, followed by 3 booster sessions over the subsequent 6 months, and were encouraged to practice at home. Self-report measures of sleep disturbances (Pittsburgh Sleep Quality Index), fatigue (Brief Fatigue Inventory), and actigraphy were collected at baseline; 1 week after treatment; and at 3, 6, and 12 months. RESULTS: There were no group differences noted in total sleep disturbances or fatigue levels over time. However, patients in the TYP group reported fewer daily disturbances 1 week after treatment compared with those in the STP (difference, -0.43; 95% confidence interval [95% CI], -0.82 to -0.04 [P =.03]) and UC (difference, -0.41; 95% CI, -0.77 to -0.05 [P =.02]) groups. Group differences at the other time points were maintained for TYP versus STP. Actigraphy data revealed greater minutes awake after sleep onset for patients in the STP group 1 week after treatment versus those in the TYP (difference, 15.36; 95% CI, 7.25-23.48 [P =.0003]) and UC (difference, 14.48; 95% CI, 7.09-21.87 [P =.0002]) groups. Patients in the TYP group who practiced at least 2 times a week during follow-up reported better Pittsburgh Sleep Quality Index and actigraphy outcomes at 3 months and 6 months after treatment compared with those who did not and better outcomes compared with those in the UC group. CONCLUSIONS: Participating in TYP during chemotherapy resulted in modest short-term benefits in sleep quality, with long-term benefits emerging over time for those who practiced TYP at least 2 times a week. Cancer 2018;124:36-45.

AB - BACKGROUND: The current randomized trial examined the effects of a Tibetan yoga program (TYP) versus a stretching program (STP) and usual care (UC) on sleep and fatigue in women with breast cancer who were undergoing chemotherapy. METHODS: Women with stage (American Joint Committee on Cancer (AJCC) TNM) I to III breast cancer who were undergoing chemotherapy were randomized to TYP (74 women), STP (68 women), or UC (85 women). Participants in the TYP and STP groups participated in 4 sessions during chemotherapy, followed by 3 booster sessions over the subsequent 6 months, and were encouraged to practice at home. Self-report measures of sleep disturbances (Pittsburgh Sleep Quality Index), fatigue (Brief Fatigue Inventory), and actigraphy were collected at baseline; 1 week after treatment; and at 3, 6, and 12 months. RESULTS: There were no group differences noted in total sleep disturbances or fatigue levels over time. However, patients in the TYP group reported fewer daily disturbances 1 week after treatment compared with those in the STP (difference, -0.43; 95% confidence interval [95% CI], -0.82 to -0.04 [P =.03]) and UC (difference, -0.41; 95% CI, -0.77 to -0.05 [P =.02]) groups. Group differences at the other time points were maintained for TYP versus STP. Actigraphy data revealed greater minutes awake after sleep onset for patients in the STP group 1 week after treatment versus those in the TYP (difference, 15.36; 95% CI, 7.25-23.48 [P =.0003]) and UC (difference, 14.48; 95% CI, 7.09-21.87 [P =.0002]) groups. Patients in the TYP group who practiced at least 2 times a week during follow-up reported better Pittsburgh Sleep Quality Index and actigraphy outcomes at 3 months and 6 months after treatment compared with those who did not and better outcomes compared with those in the UC group. CONCLUSIONS: Participating in TYP during chemotherapy resulted in modest short-term benefits in sleep quality, with long-term benefits emerging over time for those who practiced TYP at least 2 times a week. Cancer 2018;124:36-45.

KW - Tibetan yoga

KW - breast cancer

KW - chemotherapy

KW - patients

KW - sleep quality

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AN - SCOPUS:85030228829

SN - 0008-543X

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JO - Cancer

JF - Cancer

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ER -

Randomized trial of Tibetan yoga in patients with breast cancer undergoing chemotherapy

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

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