Rational ligand choice extends the SABRE substrate scope

Johannes F.P. Colell; Angus W.J. Logan; Zijian Zhou; Jacob R. Lindale; Raul Laasner; Roman V. Shchepin; Eduard Y. Chekmenev; Volker Blum; Warren S. Warren; Steven J. Malcolmson; Thomas Theis

doi:10.1039/d0cc01330g

Rational ligand choice extends the SABRE substrate scope

Johannes F.P. Colell, Angus W.J. Logan, Zijian Zhou, Jacob R. Lindale, Raul Laasner, Roman V. Shchepin, Eduard Y. Chekmenev, Volker Blum, Warren S. Warren, Steven J. Malcolmson, Thomas Theis

Research output: Contribution to journal › Article › peer-review

21 Scopus citations

Abstract

Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B6 and caffeine. We also show 15N-enhancements of ∼1000-fold and 19F-enhancements of 30-fold.

Original language	English (US)
Pages (from-to)	9336-9339
Number of pages	4
Journal	Chemical Communications
Volume	56
Issue number	65
DOIs	https://doi.org/10.1039/d0cc01330g
State	Published - Aug 21 2020
Externally published	Yes

ASJC Scopus subject areas

Catalysis
Electronic, Optical and Magnetic Materials
Ceramics and Composites
General Chemistry
Surfaces, Coatings and Films
Metals and Alloys
Materials Chemistry

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10.1039/d0cc01330g

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title = "Rational ligand choice extends the SABRE substrate scope",

abstract = "Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B6 and caffeine. We also show 15N-enhancements of ∼1000-fold and 19F-enhancements of 30-fold.",

author = "Colell, {Johannes F.P.} and Logan, {Angus W.J.} and Zijian Zhou and Lindale, {Jacob R.} and Raul Laasner and Shchepin, {Roman V.} and Chekmenev, {Eduard Y.} and Volker Blum and Warren, {Warren S.} and Malcolmson, {Steven J.} and Thomas Theis",

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year = "2020",

month = aug,

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doi = "10.1039/d0cc01330g",

language = "English (US)",

volume = "56",

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T1 - Rational ligand choice extends the SABRE substrate scope

AU - Colell, Johannes F.P.

AU - Logan, Angus W.J.

AU - Zhou, Zijian

AU - Lindale, Jacob R.

AU - Laasner, Raul

AU - Shchepin, Roman V.

AU - Chekmenev, Eduard Y.

AU - Blum, Volker

AU - Warren, Warren S.

AU - Malcolmson, Steven J.

AU - Theis, Thomas

PY - 2020/8/21

Y1 - 2020/8/21

N2 - Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B6 and caffeine. We also show 15N-enhancements of ∼1000-fold and 19F-enhancements of 30-fold.

AB - Here we report on chelating ligands for Signal Amplification By Reversible Exchange (SABRE) catalysts that permit hyperpolarisation on otherwise sterically hindered substrates. We demonstrate 1H enhancements of ∼100-fold over 8.5 T thermal for 2-substituted pyridines, and smaller, yet significant enhancements for provitamin B6 and caffeine. We also show 15N-enhancements of ∼1000-fold and 19F-enhancements of 30-fold.

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JO - Chemical Communications

JF - Chemical Communications

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ER -

Rational ligand choice extends the SABRE substrate scope

Abstract

ASJC Scopus subject areas

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