Reactive oxygen species, SUMOylation, and endothelial inflammation

Nhat Tu Le, James P. Corsetti, Janet L. Dehoff-Sparks, Charles E. Sparks, Keigi Fujiwara, Jun Ichi Abe

Research output: Contribution to journalReview article

12 Citations (Scopus)

Abstract

Although the exact mechanism through which NADPH oxidases (Nox's) generate reactive oxygen species (ROS) is still not completely understood, it is widely considered that ROS accumulation is the cause of oxidative stress in endothelial cells. Increasing pieces of evidence strongly indicate the role for ROS in endothelial inflammation and dysfunction and subsequent development of atherosclerotic plaques, which are causes of various pathological cardiac events. An overview for a causative relationship between ROS and endothelial inflammation will be provided in this review. Particularly, a crucial role for specific protein SUMOylation in endothelial inflammation will be presented. Given that SUMOylation of specific proteins leads to increased endothelial inflammation, targeting specific SUMOylated proteins may be an elegant, effective strategy to control inflammation. In addition, the involvement of ROS production in increasing the risk of recurrent coronary events in a sub-group of non-diabetic, post-infarction patients with elevated levels of HDL-cholesterol will be presented with the emphasis that elevated HDL-cholesterol under certain inflammatory conditions can lead to increased incidence of cardiovascular events.

Original languageEnglish (US)
Article number678190
JournalInternational Journal of Inflammation
Volume2012
DOIs
StatePublished - Nov 7 2012

Fingerprint

Sumoylation
Reactive Oxygen Species
Inflammation
HDL Cholesterol
Proteins
NADPH Oxidase
Atherosclerotic Plaques
Hypercholesterolemia
Infarction
Oxidative Stress
Endothelial Cells
Incidence

ASJC Scopus subject areas

  • Immunology and Allergy

Cite this

Reactive oxygen species, SUMOylation, and endothelial inflammation. / Le, Nhat Tu; Corsetti, James P.; Dehoff-Sparks, Janet L.; Sparks, Charles E.; Fujiwara, Keigi; Abe, Jun Ichi.

In: International Journal of Inflammation, Vol. 2012, 678190, 07.11.2012.

Research output: Contribution to journalReview article

Le, Nhat Tu ; Corsetti, James P. ; Dehoff-Sparks, Janet L. ; Sparks, Charles E. ; Fujiwara, Keigi ; Abe, Jun Ichi. / Reactive oxygen species, SUMOylation, and endothelial inflammation. In: International Journal of Inflammation. 2012 ; Vol. 2012.
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