Real-Time Interrogation of Aspirin Reactivity, Biochemistry, and Biodistribution by Hyperpolarized Magnetic Resonance Spectroscopy

Research output: Contribution to journalArticlepeer-review

8 Scopus citations

Abstract

Hyperpolarized magnetic resonance spectroscopy enables quantitative, non-radioactive, real-time measurement of imaging probe biodistribution and metabolism in vivo. Here, we investigate and report on the development and characterization of hyperpolarized acetylsalicylic acid (aspirin) and its use as a nuclear magnetic resonance (NMR) probe. Aspirin derivatives were synthesized with single- and double- 13 C labels and hyperpolarized by dynamic nuclear polarization with 4.7 % and 3 % polarization, respectively. The longitudinal relaxation constants (T 1 ) for the labeled acetyl and carboxyl carbonyls were approximately 30 seconds, supporting in vivo imaging and spectroscopy applications. In vitro hydrolysis, transacetylation, and albumin binding of hyperpolarized aspirin were readily monitored in real time by 13 C-NMR spectroscopy. Hyperpolarized, double-labeled aspirin was well tolerated in mice and could be observed by both 13 C-MR imaging and 13 C-NMR spectroscopy in vivo.

Original languageEnglish (US)
Pages (from-to)4179-4183
Number of pages5
JournalAngewandte Chemie - International Edition
Volume58
Issue number13
DOIs
StatePublished - Mar 22 2019

Keywords

  • aspirin
  • chemopreventive
  • hyperpolarization
  • magnetic resonance imaging
  • magnetic resonance spectroscopy

ASJC Scopus subject areas

  • Catalysis
  • General Chemistry

MD Anderson CCSG core facilities

  • Research Animal Support Facility
  • Small Animal Imaging Facility
  • NMR Facility

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