TY - JOUR
T1 - Recent Advances in Adult Acute Lymphoblastic Leukemia
AU - Richard-Carpentier, Guillaume
AU - Kantarjian, Hagop
AU - Jabbour, Elias
N1 - Publisher Copyright:
© 2019, Springer Science+Business Media, LLC, part of Springer Nature.
Copyright:
Copyright 2019 Elsevier B.V., All rights reserved.
PY - 2019/1/1
Y1 - 2019/1/1
N2 - Purpose of Review: This article reviews the recent advances in the pathophysiology and management of acute lymphoblastic leukemia (ALL) in adults. Recent Findings: Addition of rituximab to standard chemotherapy improves survival in the frontline treatment of B cell ALL, and measurable residual disease (MRD) is the most important prognostic factor. Tyrosine kinase inhibitors (TKI), particularly ponatinib, in combination with Hyper-CVAD significantly improve outcomes in Ph + ALL challenging the benefit of allogeneic stem cell transplant in first line for these patients. Blinatumomab, inotuzumab ozogamicin, and chimeric antigen receptor (CAR) T cells are better options than chemotherapy alone for the treatment of relapsed or refractory ALL. Combination of these agents with chemotherapy and their incorporation in the frontline setting show promises to improve cure rates of ALL. Summary: Development of monoclonal antibodies, CAR T, and potent TKI has improved the outcome of ALL. Advances in our understanding of ALL biology are expected to bring new therapeutic strategies in the upcoming years.
AB - Purpose of Review: This article reviews the recent advances in the pathophysiology and management of acute lymphoblastic leukemia (ALL) in adults. Recent Findings: Addition of rituximab to standard chemotherapy improves survival in the frontline treatment of B cell ALL, and measurable residual disease (MRD) is the most important prognostic factor. Tyrosine kinase inhibitors (TKI), particularly ponatinib, in combination with Hyper-CVAD significantly improve outcomes in Ph + ALL challenging the benefit of allogeneic stem cell transplant in first line for these patients. Blinatumomab, inotuzumab ozogamicin, and chimeric antigen receptor (CAR) T cells are better options than chemotherapy alone for the treatment of relapsed or refractory ALL. Combination of these agents with chemotherapy and their incorporation in the frontline setting show promises to improve cure rates of ALL. Summary: Development of monoclonal antibodies, CAR T, and potent TKI has improved the outcome of ALL. Advances in our understanding of ALL biology are expected to bring new therapeutic strategies in the upcoming years.
KW - Acute lymphoblastic leukemia
KW - Chimeric antigen receptor T cells
KW - Management
KW - Monoclonal antibodies
KW - Treatment
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U2 - 10.1007/s11899-019-00503-1
DO - 10.1007/s11899-019-00503-1
M3 - Review article
C2 - 30879177
AN - SCOPUS:85063100591
SN - 1558-8211
JO - Current hematologic malignancy reports
JF - Current hematologic malignancy reports
ER -