Abstract
Desmoplastic small round cell tumor (DSRCT) is a rare mesenchymal tumor that typically presents with multiple abdominal masses. Initial treatment is multimodal in nature. Patients with relapsed DSRCT have a poor prognosis, and there are no standard therapies. We report our experience with five patients treated with vinorelbine, cyclophosphamide, and temsirolimus (VCT). Median number of VCT courses delivered was 7 (range 4–14 courses), and partial response was observed in all patients. Median time to progression or relapse was 8.5 months (range 7–16 months). Neutropenia and mucositis were most common toxicities (n = 4 each).
Original language | English (US) |
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Article number | e26768 |
Journal | Pediatric Blood and Cancer |
Volume | 65 |
Issue number | 1 |
DOIs | |
State | Published - Jan 2018 |
Keywords
- childhood cancer
- desmoplastic
- recurrence
- sarcoma
- temsirolimus
ASJC Scopus subject areas
- Pediatrics, Perinatology, and Child Health
- Hematology
- Oncology