Recurrent secondary pneumothorax caused by bronchiolitis obliterans due to chronic graft versus host disease in a patient with chronic myelogenous leukemia after allogenic bone marrow transplantation

Chul Min Ahn, Sang Yun Hwang, Min Kwang Byun, Jin Hyoung Lee, Wou Young Chung, Jin Wook Moon, Moo Suk Park, Yoo Hong Min, Se Kyu Kim, Joon Chang, Sung Kyu Kim, Haeryoung Kim, Hoguen Kim, Young Sam Kim

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    1 Scopus citations

    Abstract

    Bronchiolitis obliterans (BO) is a nonspecific inflammatory injury affecting primarily the small airways. Its inflammatory process is characterized by fibrotic obliteration of the lumen of bronchioles. BO can be idiopathic or associated with connective tissue disease, inhaled toxins, infections, drugs, and chronic graft-versus-host-disease (GVHD). Pulmonary complications occur in 40-60% of patients who undergo allogeneic bone marrow transplantation (BMT), causing 10-40% of transplant-related deaths, BO is a characteristic pulmonary complication which occurs usually within a few years after BMT. Documented complications of BO include air-leak syndromes such as pneumomediastinum, subcutaneous emphysema and pneumothorax. We report a case of a 30-year-old male patient with BO due to chronic GVHD after allogenic BMT who presented with recurrent bilateral pneumothoraces.

    Original languageEnglish (US)
    Pages (from-to)183-187
    Number of pages5
    JournalTuberculosis and Respiratory Diseases
    Volume57
    Issue number2
    StatePublished - Aug 1 2004

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    Keywords

    • Air-leak syndrome
    • Bone marrow transplantation
    • Bronchiolitis obliterans
    • Graft-versus-host- disease
    • Pneumothorax

    ASJC Scopus subject areas

    • Pulmonary and Respiratory Medicine
    • Infectious Diseases

    Cite this

    Ahn, C. M., Hwang, S. Y., Byun, M. K., Lee, J. H., Chung, W. Y., Moon, J. W., Park, M. S., Min, Y. H., Kim, S. K., Chang, J., Kim, S. K., Kim, H., Kim, H., & Kim, Y. S. (2004). Recurrent secondary pneumothorax caused by bronchiolitis obliterans due to chronic graft versus host disease in a patient with chronic myelogenous leukemia after allogenic bone marrow transplantation. Tuberculosis and Respiratory Diseases, 57(2), 183-187.