Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase

Ali Zhang, Quansheng Wang, Zhiqiang Han, Wei Hu, Ling Xi, Qinlei Gao, Shixuan Wang, Jianfeng Zhou, Gang Xu, Li Meng, Gang Chen, Ding Ma

Research output: Contribution to journalArticle

17 Citations (Scopus)

Abstract

Several lines of evidence support an important role for Snail, a transcriptional factor, in breast cancer. Overexpression of Snail has been associated with breast cancer metastasis, although the specific role of Snail in the process remains unclear. To address this issue, the expression levels of Snail, RhoA and fibronectin, as well as MMP-2, were reduced in the breast tumor cell lines MDA-MB-231 and MDA-MB-435S, and their biological responses were studied in vitro and in vivo. For the first time, it was observed that downregulated Snail expression is correlated with a significant inhibition of the expression and activity of RhoA GTPase, as well as MMP-2. The present data provide evidence that Snail promotes tumor cell motility and angiogenesis which is mainly mediated through the regulation of RhoA activity. In conclusion, the present findings demonstrate a key regulatory role for Snail in breast tumor growth and progression.

Original languageEnglish (US)
Pages (from-to)339-346
Number of pages8
JournalOncology Letters
Volume6
Issue number2
DOIs
StatePublished - Aug 1 2013

Fingerprint

GTP Phosphohydrolases
Cell Movement
Down-Regulation
Breast Neoplasms
Matrix Metalloproteinases
Snails
Tumor Cell Line
Fibronectins
Neoplasm Metastasis
Growth
Neoplasms

Keywords

  • Breast cancer
  • Metastasis
  • RhoA GTPase
  • Snail

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase. / Zhang, Ali; Wang, Quansheng; Han, Zhiqiang; Hu, Wei; Xi, Ling; Gao, Qinlei; Wang, Shixuan; Zhou, Jianfeng; Xu, Gang; Meng, Li; Chen, Gang; Ma, Ding.

In: Oncology Letters, Vol. 6, No. 2, 01.08.2013, p. 339-346.

Research output: Contribution to journalArticle

Zhang, Ali ; Wang, Quansheng ; Han, Zhiqiang ; Hu, Wei ; Xi, Ling ; Gao, Qinlei ; Wang, Shixuan ; Zhou, Jianfeng ; Xu, Gang ; Meng, Li ; Chen, Gang ; Ma, Ding. / Reduced expression of Snail decreases breast cancer cell motility by downregulating the expression and inhibiting the activity of RhoA GTPase. In: Oncology Letters. 2013 ; Vol. 6, No. 2. pp. 339-346.
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AU - Gao, Qinlei

AU - Wang, Shixuan

AU - Zhou, Jianfeng

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