Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

Salvatore De Rosa; Carmen Spaccarotella; Cristina Basso; Maria Pia Calabrò; Antonio Curcio; Pasquale Perrone Filardi; Massimo Mancone; Giuseppe Mercuro; Saverio Muscoli; Savina Nodari; Roberto Pedrinelli; Gianfranco Sinagra; Ciro Indolfi; Filippo Angelini; Francesco Barillà; Antonio Bartorelli; Francesco Benedetto; Paola Bernabò; Leonardo Bolognese; Martina Briani; Luisa Cacciavillani; Alice Calabrese; Paolo Calabrò; Luigi Caliendo; Leonardo Calò; Gianni Casella; Gavino Casu; Claudio Cavallini; Quirino Ciampi; Marco Ciccone; Michele Comito; Elena Corrada; Filippo Crea; Antonello D'Andrea; Maurizio D'Urbano; Raffaele De Caterina; Gaetano De Ferrari; Roberto De Ponti; Alessio Della Mattia; Carlo DI Mario; Luca Donnazzan; Giovanni Esposito; Francesco Fedele; Alessandro Ferraro; Gennaro Galasso; Nazzareno Galiè; Massimiliano Gnecchi; Paolo Golino; Bruno Golia; Pasquale Guarini; Sergio Leonardi; Nicola Locuratolo; Francesco Luzza; Vincenzo Manganiello; Maria Francesca Marchetti; Giancarlo Marenzi; Alberto Margonato; Luigi Meloni; Marco Metra; Marco Milo; Annalisa Mongiardo; Luca Monzo; Carmine Morisco; Savina Nodari; Giuseppina Novo; Stefano Pancaldi; Matteo Parollo; Giovanni Paternò; Giuseppe Patti; Silvia Priori; Amelia Ravera; Antonio Giuseppe Rebuzzi; Massimo Rossi; Marino Scherillo; Franco Semprini; Michele Senni; Gerolamo Sibilio; Massimo Siviglia; Corrado Tamburino; Gianfranco Tortorici; Francesco Versace; Bruno Villari; Massimo Volpe

doi:10.1093/eurheartj/ehaa409

Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

Salvatore De Rosa, Carmen Spaccarotella, Cristina Basso, Maria Pia Calabrò, Antonio Curcio, Pasquale Perrone Filardi, Massimo Mancone, Giuseppe Mercuro, Saverio Muscoli, Savina Nodari, Roberto Pedrinelli, Gianfranco Sinagra, Ciro Indolfi, Filippo Angelini, Francesco Barillà, Antonio Bartorelli, Francesco Benedetto, Paola Bernabò, Leonardo Bolognese, Martina BrianiLuisa Cacciavillani, Alice Calabrese, Paolo Calabrò, Luigi Caliendo, Leonardo Calò, Gianni Casella, Gavino Casu, Claudio Cavallini, Quirino Ciampi, Marco Ciccone, Michele Comito, Elena Corrada, Filippo Crea, Antonello D'Andrea, Maurizio D'Urbano, Raffaele De Caterina, Gaetano De Ferrari, Roberto De Ponti, Alessio Della Mattia, Carlo DI Mario, Luca Donnazzan, Giovanni Esposito, Francesco Fedele, Alessandro Ferraro, Gennaro Galasso, Nazzareno Galiè, Massimiliano Gnecchi, Paolo Golino, Bruno Golia, Pasquale Guarini, Sergio Leonardi, Nicola Locuratolo, Francesco Luzza, Vincenzo Manganiello, Maria Francesca Marchetti, Giancarlo Marenzi, Alberto Margonato, Luigi Meloni, Marco Metra, Marco Milo, Annalisa Mongiardo, Luca Monzo, Carmine Morisco, Savina Nodari, Giuseppina Novo, Stefano Pancaldi, Matteo Parollo, Giovanni Paternò, Giuseppe Patti, Silvia Priori, Amelia Ravera, Antonio Giuseppe Rebuzzi, Massimo Rossi, Marino Scherillo, Franco Semprini, Michele Senni, Gerolamo Sibilio, Massimo Siviglia, Corrado Tamburino, Gianfranco Tortorici, Francesco Versace, Bruno Villari, Massimo Volpe

Behavioral Science

Research output: Contribution to journal › Article › peer-review

690 Scopus citations

Abstract

Aims: To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results: We conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7-32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3-70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7-6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1-2.8; P = 0.009). Conclusion: Admissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.

Original language	English (US)
Pages (from-to)	2083-2088
Number of pages	6
Journal	European heart journal
Volume	41
Issue number	22
DOIs	https://doi.org/10.1093/eurheartj/ehaa409
State	Published - Jun 7 2020

Keywords

Acute myocardial infarction
COVID-19
Cardiac care units
SARS-CoV2
STEMI

ASJC Scopus subject areas

Cardiology and Cardiovascular Medicine

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10.1093/eurheartj/ehaa409

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De Rosa, S., Spaccarotella, C., Basso, C., Calabrò, M. P., Curcio, A., Filardi, P. P., Mancone, M., Mercuro, G., Muscoli, S., Nodari, S., Pedrinelli, R., Sinagra, G., Indolfi, C., Angelini, F., Barillà, F., Bartorelli, A., Benedetto, F., Bernabò, P., Bolognese, L., ... Volpe, M. (2020). Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era. European heart journal, 41(22), 2083-2088. https://doi.org/10.1093/eurheartj/ehaa409

De Rosa, S, Spaccarotella, C, Basso, C, Calabrò, MP, Curcio, A, Filardi, PP, Mancone, M, Mercuro, G, Muscoli, S, Nodari, S, Pedrinelli, R, Sinagra, G, Indolfi, C, Angelini, F, Barillà, F, Bartorelli, A, Benedetto, F, Bernabò, P, Bolognese, L, Briani, M, Cacciavillani, L, Calabrese, A, Calabrò, P, Caliendo, L, Calò, L, Casella, G, Casu, G, Cavallini, C, Ciampi, Q, Ciccone, M, Comito, M, Corrada, E, Crea, F, D'Andrea, A, D'Urbano, M, De Caterina, R, De Ferrari, G, De Ponti, R, Della Mattia, A, DI Mario, C, Donnazzan, L, Esposito, G, Fedele, F, Ferraro, A, Galasso, G, Galiè, N, Gnecchi, M, Golino, P, Golia, B, Guarini, P, Leonardi, S, Locuratolo, N, Luzza, F, Manganiello, V, Francesca Marchetti, M, Marenzi, G, Margonato, A, Meloni, L, Metra, M, Milo, M, Mongiardo, A, Monzo, L, Morisco, C, Nodari, S, Novo, G, Pancaldi, S, Parollo, M, Paternò, G, Patti, G, Priori, S, Ravera, A, Giuseppe Rebuzzi, A, Rossi, M, Scherillo, M, Semprini, F, Senni, M, Sibilio, G, Siviglia, M, Tamburino, C, Tortorici, G, Versace, F, Villari, B & Volpe, M 2020, 'Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era', European heart journal, vol. 41, no. 22, pp. 2083-2088. https://doi.org/10.1093/eurheartj/ehaa409

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title = "Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era",

abstract = "Aims: To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results: We conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7-32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3-70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7-6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1-2.8; P = 0.009). Conclusion: Admissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.",

keywords = "Acute myocardial infarction, COVID-19, Cardiac care units, SARS-CoV2, STEMI",

author = "{De Rosa}, Salvatore and Carmen Spaccarotella and Cristina Basso and Calabr{\`o}, {Maria Pia} and Antonio Curcio and Filardi, {Pasquale Perrone} and Massimo Mancone and Giuseppe Mercuro and Saverio Muscoli and Savina Nodari and Roberto Pedrinelli and Gianfranco Sinagra and Ciro Indolfi and Filippo Angelini and Francesco Barill{\`a} and Antonio Bartorelli and Francesco Benedetto and Paola Bernab{\`o} and Leonardo Bolognese and Martina Briani and Luisa Cacciavillani and Alice Calabrese and Paolo Calabr{\`o} and Luigi Caliendo and Leonardo Cal{\`o} and Gianni Casella and Gavino Casu and Claudio Cavallini and Quirino Ciampi and Marco Ciccone and Michele Comito and Elena Corrada and Filippo Crea and Antonello D'Andrea and Maurizio D'Urbano and {De Caterina}, Raffaele and {De Ferrari}, Gaetano and {De Ponti}, Roberto and {Della Mattia}, Alessio and {DI Mario}, Carlo and Luca Donnazzan and Giovanni Esposito and Francesco Fedele and Alessandro Ferraro and Gennaro Galasso and Nazzareno Gali{\`e} and Massimiliano Gnecchi and Paolo Golino and Bruno Golia and Pasquale Guarini and Sergio Leonardi and Nicola Locuratolo and Francesco Luzza and Vincenzo Manganiello and {Francesca Marchetti}, Maria and Giancarlo Marenzi and Alberto Margonato and Luigi Meloni and Marco Metra and Marco Milo and Annalisa Mongiardo and Luca Monzo and Carmine Morisco and Savina Nodari and Giuseppina Novo and Stefano Pancaldi and Matteo Parollo and Giovanni Patern{\`o} and Giuseppe Patti and Silvia Priori and Amelia Ravera and {Giuseppe Rebuzzi}, Antonio and Massimo Rossi and Marino Scherillo and Franco Semprini and Michele Senni and Gerolamo Sibilio and Massimo Siviglia and Corrado Tamburino and Gianfranco Tortorici and Francesco Versace and Bruno Villari and Massimo Volpe",

year = "2020",

month = jun,

day = "7",

doi = "10.1093/eurheartj/ehaa409",

language = "English (US)",

volume = "41",

pages = "2083--2088",

journal = "European heart journal",

issn = "0195-668X",

publisher = "Oxford University Press",

number = "22",

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TY - JOUR

T1 - Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

AU - De Rosa, Salvatore

AU - Spaccarotella, Carmen

AU - Basso, Cristina

AU - Calabrò, Maria Pia

AU - Curcio, Antonio

AU - Filardi, Pasquale Perrone

AU - Mancone, Massimo

AU - Mercuro, Giuseppe

AU - Muscoli, Saverio

AU - Nodari, Savina

AU - Pedrinelli, Roberto

AU - Sinagra, Gianfranco

AU - Indolfi, Ciro

AU - Angelini, Filippo

AU - Barillà, Francesco

AU - Bartorelli, Antonio

AU - Benedetto, Francesco

AU - Bernabò, Paola

AU - Bolognese, Leonardo

AU - Briani, Martina

AU - Cacciavillani, Luisa

AU - Calabrese, Alice

AU - Calabrò, Paolo

AU - Caliendo, Luigi

AU - Calò, Leonardo

AU - Casella, Gianni

AU - Casu, Gavino

AU - Cavallini, Claudio

AU - Ciampi, Quirino

AU - Ciccone, Marco

AU - Comito, Michele

AU - Corrada, Elena

AU - Crea, Filippo

AU - D'Andrea, Antonello

AU - D'Urbano, Maurizio

AU - De Caterina, Raffaele

AU - De Ferrari, Gaetano

AU - De Ponti, Roberto

AU - Della Mattia, Alessio

AU - DI Mario, Carlo

AU - Donnazzan, Luca

AU - Esposito, Giovanni

AU - Fedele, Francesco

AU - Ferraro, Alessandro

AU - Galasso, Gennaro

AU - Galiè, Nazzareno

AU - Gnecchi, Massimiliano

AU - Golino, Paolo

AU - Golia, Bruno

AU - Guarini, Pasquale

AU - Leonardi, Sergio

AU - Locuratolo, Nicola

AU - Luzza, Francesco

AU - Manganiello, Vincenzo

AU - Francesca Marchetti, Maria

AU - Marenzi, Giancarlo

AU - Margonato, Alberto

AU - Meloni, Luigi

AU - Metra, Marco

AU - Milo, Marco

AU - Mongiardo, Annalisa

AU - Monzo, Luca

AU - Morisco, Carmine

AU - Nodari, Savina

AU - Novo, Giuseppina

AU - Pancaldi, Stefano

AU - Parollo, Matteo

AU - Paternò, Giovanni

AU - Patti, Giuseppe

AU - Priori, Silvia

AU - Ravera, Amelia

AU - Giuseppe Rebuzzi, Antonio

AU - Rossi, Massimo

AU - Scherillo, Marino

AU - Semprini, Franco

AU - Senni, Michele

AU - Sibilio, Gerolamo

AU - Siviglia, Massimo

AU - Tamburino, Corrado

AU - Tortorici, Gianfranco

AU - Versace, Francesco

AU - Villari, Bruno

AU - Volpe, Massimo

PY - 2020/6/7

Y1 - 2020/6/7

N2 - Aims: To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results: We conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7-32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3-70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7-6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1-2.8; P = 0.009). Conclusion: Admissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.

AB - Aims: To evaluate the impact of the COVID-19 pandemic on patient admissions to Italian cardiac care units (CCUs). Methods and Results: We conducted a multicentre, observational, nationwide survey to collect data on admissions for acute myocardial infarction (AMI) at Italian CCUs throughout a 1 week period during the COVID-19 outbreak, compared with the equivalent week in 2019. We observed a 48.4% reduction in admissions for AMI compared with the equivalent week in 2019 (P < 0.001). The reduction was significant for both ST-segment elevation myocardial infarction [STEMI; 26.5%, 95% confidence interval (CI) 21.7-32.3; P = 0.009] and non-STEMI (NSTEMI; 65.1%, 95% CI 60.3-70.3; P < 0.001). Among STEMIs, the reduction was higher for women (41.2%; P = 0.011) than men (17.8%; P = 0.191). A similar reduction in AMI admissions was registered in North Italy (52.1%), Central Italy (59.3%), and South Italy (52.1%). The STEMI case fatality rate during the pandemic was substantially increased compared with 2019 [risk ratio (RR) = 3.3, 95% CI 1.7-6.6; P < 0.001]. A parallel increase in complications was also registered (RR = 1.8, 95% CI 1.1-2.8; P = 0.009). Conclusion: Admissions for AMI were significantly reduced during the COVID-19 pandemic across Italy, with a parallel increase in fatality and complication rates. This constitutes a serious social issue, demanding attention by the scientific and healthcare communities and public regulatory agencies.

KW - Acute myocardial infarction

KW - COVID-19

KW - Cardiac care units

KW - SARS-CoV2

KW - STEMI

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U2 - 10.1093/eurheartj/ehaa409

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JO - European heart journal

JF - European heart journal

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ER -

Reduction of hospitalizations for myocardial infarction in Italy in the COVID-19 era

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