Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

Wei Rao; Shan Wang; Marcin Duleba; Suchan Niroula; Kristina Goller; Jingzhong Xie; Rajasekaran Mahalingam; Rahul Neupane; Audrey Ann Liew; Matthew Vincent; Kenichi Okuda; Wanda K. O'Neal; Richard C. Boucher; Burton F. Dickey; Michael E. Wechsler; Omar Ibrahim; John F. Engelhardt; Tinne C.J. Mertens; Wei Wang; Soma S.K. Jyothula; Christopher P. Crum; Harry Karmouty-Quintana; Kalpaj R. Parekh; Mark L. Metersky; Frank D. McKeon; Wa Xian

doi:10.1016/j.cell.2020.03.047

Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

Wei Rao, Shan Wang, Marcin Duleba, Suchan Niroula, Kristina Goller, Jingzhong Xie, Rajasekaran Mahalingam, Rahul Neupane, Audrey Ann Liew, Matthew Vincent, Kenichi Okuda, Wanda K. O'Neal, Richard C. Boucher, Burton F. Dickey, Michael E. Wechsler, Omar Ibrahim, John F. Engelhardt, Tinne C.J. Mertens, Wei Wang, Soma S.K. JyothulaChristopher P. Crum, Harry Karmouty-Quintana, Kalpaj R. Parekh, Mark L. Metersky, Frank D. McKeon, Wa Xian

Pulmonary Medicine

Research output: Contribution to journal › Article › peer-review

82 Scopus citations

Abstract

The hallmark features of COPD (inflammation, fibrosis, and mucus hypersecretion) are driven by distinct pathogenic progenitors which pre-exist as minor populations in healthy lungs but dominate in the disease state relative to normal lung stem cells.

Original language	English (US)
Pages (from-to)	848-864.e18
Journal	Cell
Volume	181
Issue number	4
DOIs	https://doi.org/10.1016/j.cell.2020.03.047
State	Published - May 14 2020

Keywords

COPD
chronic lung disease
fibrosis
inflammation
lung
metaplasia
myofibroblasts
neutrophils
p63
single cell cloning
stem cells

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

MD Anderson CCSG core facilities

Flow Cytometry and Cellular Imaging Facility

Access to Document

10.1016/j.cell.2020.03.047

Cite this

Rao, W., Wang, S., Duleba, M., Niroula, S., Goller, K., Xie, J., Mahalingam, R., Neupane, R., Liew, A. A., Vincent, M., Okuda, K., O'Neal, W. K., Boucher, R. C., Dickey, B. F., Wechsler, M. E., Ibrahim, O., Engelhardt, J. F., Mertens, T. C. J., Wang, W., ... Xian, W. (2020). Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis. Cell, 181(4), 848-864.e18. https://doi.org/10.1016/j.cell.2020.03.047

Rao, W, Wang, S, Duleba, M, Niroula, S, Goller, K, Xie, J, Mahalingam, R, Neupane, R, Liew, AA, Vincent, M, Okuda, K, O'Neal, WK, Boucher, RC, Dickey, BF, Wechsler, ME, Ibrahim, O, Engelhardt, JF, Mertens, TCJ, Wang, W, Jyothula, SSK, Crum, CP, Karmouty-Quintana, H, Parekh, KR, Metersky, ML, McKeon, FD & Xian, W 2020, 'Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis', Cell, vol. 181, no. 4, pp. 848-864.e18. https://doi.org/10.1016/j.cell.2020.03.047

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title = "Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis",

abstract = "The hallmark features of COPD (inflammation, fibrosis, and mucus hypersecretion) are driven by distinct pathogenic progenitors which pre-exist as minor populations in healthy lungs but dominate in the disease state relative to normal lung stem cells.",

keywords = "COPD, chronic lung disease, fibrosis, inflammation, lung, metaplasia, myofibroblasts, neutrophils, p63, single cell cloning, stem cells",

author = "Wei Rao and Shan Wang and Marcin Duleba and Suchan Niroula and Kristina Goller and Jingzhong Xie and Rajasekaran Mahalingam and Rahul Neupane and Liew, {Audrey Ann} and Matthew Vincent and Kenichi Okuda and O'Neal, {Wanda K.} and Boucher, {Richard C.} and Dickey, {Burton F.} and Wechsler, {Michael E.} and Omar Ibrahim and Engelhardt, {John F.} and Mertens, {Tinne C.J.} and Wei Wang and Jyothula, {Soma S.K.} and Crum, {Christopher P.} and Harry Karmouty-Quintana and Parekh, {Kalpaj R.} and Metersky, {Mark L.} and McKeon, {Frank D.} and Wa Xian",

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doi = "10.1016/j.cell.2020.03.047",

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AU - Rao, Wei

AU - Wang, Shan

AU - Duleba, Marcin

AU - Niroula, Suchan

AU - Goller, Kristina

AU - Xie, Jingzhong

AU - Mahalingam, Rajasekaran

AU - Neupane, Rahul

AU - Liew, Audrey Ann

AU - Vincent, Matthew

AU - Okuda, Kenichi

AU - O'Neal, Wanda K.

AU - Boucher, Richard C.

AU - Dickey, Burton F.

AU - Wechsler, Michael E.

AU - Ibrahim, Omar

AU - Engelhardt, John F.

AU - Mertens, Tinne C.J.

AU - Wang, Wei

AU - Jyothula, Soma S.K.

AU - Crum, Christopher P.

AU - Karmouty-Quintana, Harry

AU - Parekh, Kalpaj R.

AU - Metersky, Mark L.

AU - McKeon, Frank D.

AU - Xian, Wa

PY - 2020/5/14

Y1 - 2020/5/14

N2 - The hallmark features of COPD (inflammation, fibrosis, and mucus hypersecretion) are driven by distinct pathogenic progenitors which pre-exist as minor populations in healthy lungs but dominate in the disease state relative to normal lung stem cells.

AB - The hallmark features of COPD (inflammation, fibrosis, and mucus hypersecretion) are driven by distinct pathogenic progenitors which pre-exist as minor populations in healthy lungs but dominate in the disease state relative to normal lung stem cells.

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KW - chronic lung disease

KW - fibrosis

KW - inflammation

KW - lung

KW - metaplasia

KW - myofibroblasts

KW - neutrophils

KW - p63

KW - single cell cloning

KW - stem cells

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Regenerative Metaplastic Clones in COPD Lung Drive Inflammation and Fibrosis

Abstract

Keywords

ASJC Scopus subject areas

MD Anderson CCSG core facilities

Access to Document

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