Regulation of cell transformation by Rb-controlled redox homeostasis

Zhongling Zhu, Yuanyuan Wang, Zheng Liang, Wenwen Wang, Huamei Zhang, Binghui Li, Guoguang Ying

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    4 Scopus citations

    Abstract

    Rb is a tumor suppressor, and regulates various biological progresses, such as cell proliferation, development, metabolism and cell death. In the current study, we show that Rb knockout in 3T3 cells leads to oxidative redox state and low mitochondrial membrane potential by regulating mitochondrial activity. Our results indicate that Rb plays an important role in controlling redox homeostasis. More importantly, the functions of Rb in modulating cell proliferation, death and transformation are, at least in part, mediated by its controlling cellular redox state. In addition, our results also suggest that the cellular redox state possibly determines various biological activities, including cell survival, death and transformation, where Rb is functioning as a regulator of redox homeostasis.

    Original languageEnglish (US)
    Article numbere102582
    JournalPloS one
    Volume9
    Issue number7
    DOIs
    StatePublished - Jul 14 2014

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    ASJC Scopus subject areas

    • Biochemistry, Genetics and Molecular Biology(all)
    • Agricultural and Biological Sciences(all)
    • General

    Cite this

    Zhu, Z., Wang, Y., Liang, Z., Wang, W., Zhang, H., Li, B., & Ying, G. (2014). Regulation of cell transformation by Rb-controlled redox homeostasis. PloS one, 9(7), [e102582]. https://doi.org/10.1371/journal.pone.0102582