Regulation of In Situ to Invasive Breast Carcinoma Transition

Min Hu, Jun Yao, Danielle K. Carroll, Stanislawa Weremowicz, Haiyan Chen, Daniel Carrasco, Andrea Richardson, Shelia Violette, Tatiana Nikolskaya, Yuri Nikolsky, Erica L. Bauerlein, William C. Hahn, Rebecca S. Gelman, Craig Allred, Mina J. Bissell, Stuart Schnitt, Kornelia Polyak

Research output: Contribution to journalArticle

330 Citations (Scopus)

Abstract

The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal epithelial and myoepithelial cells identified an intricate interaction network involving TGFβ, Hedgehog, cell adhesion, and p63 required for myoepithelial cell differentiation, the elimination of which resulted in loss of myoepithelial cells and progression to invasion.

Original languageEnglish (US)
Pages (from-to)394-406
Number of pages13
JournalCancer cell
Volume13
Issue number5
DOIs
StatePublished - May 6 2008

Fingerprint

Carcinoma, Intraductal, Noninfiltrating
Breast Neoplasms
Fibroblasts
Carcinoma in Situ
Cell Adhesion
Cell Differentiation
Epithelial Cells
Carcinoma

Keywords

  • CELLBIO
  • CELLCYCLE

ASJC Scopus subject areas

  • Oncology
  • Cell Biology
  • Cancer Research

Cite this

Hu, M., Yao, J., Carroll, D. K., Weremowicz, S., Chen, H., Carrasco, D., ... Polyak, K. (2008). Regulation of In Situ to Invasive Breast Carcinoma Transition. Cancer cell, 13(5), 394-406. https://doi.org/10.1016/j.ccr.2008.03.007

Regulation of In Situ to Invasive Breast Carcinoma Transition. / Hu, Min; Yao, Jun; Carroll, Danielle K.; Weremowicz, Stanislawa; Chen, Haiyan; Carrasco, Daniel; Richardson, Andrea; Violette, Shelia; Nikolskaya, Tatiana; Nikolsky, Yuri; Bauerlein, Erica L.; Hahn, William C.; Gelman, Rebecca S.; Allred, Craig; Bissell, Mina J.; Schnitt, Stuart; Polyak, Kornelia.

In: Cancer cell, Vol. 13, No. 5, 06.05.2008, p. 394-406.

Research output: Contribution to journalArticle

Hu, M, Yao, J, Carroll, DK, Weremowicz, S, Chen, H, Carrasco, D, Richardson, A, Violette, S, Nikolskaya, T, Nikolsky, Y, Bauerlein, EL, Hahn, WC, Gelman, RS, Allred, C, Bissell, MJ, Schnitt, S & Polyak, K 2008, 'Regulation of In Situ to Invasive Breast Carcinoma Transition', Cancer cell, vol. 13, no. 5, pp. 394-406. https://doi.org/10.1016/j.ccr.2008.03.007
Hu M, Yao J, Carroll DK, Weremowicz S, Chen H, Carrasco D et al. Regulation of In Situ to Invasive Breast Carcinoma Transition. Cancer cell. 2008 May 6;13(5):394-406. https://doi.org/10.1016/j.ccr.2008.03.007
Hu, Min ; Yao, Jun ; Carroll, Danielle K. ; Weremowicz, Stanislawa ; Chen, Haiyan ; Carrasco, Daniel ; Richardson, Andrea ; Violette, Shelia ; Nikolskaya, Tatiana ; Nikolsky, Yuri ; Bauerlein, Erica L. ; Hahn, William C. ; Gelman, Rebecca S. ; Allred, Craig ; Bissell, Mina J. ; Schnitt, Stuart ; Polyak, Kornelia. / Regulation of In Situ to Invasive Breast Carcinoma Transition. In: Cancer cell. 2008 ; Vol. 13, No. 5. pp. 394-406.
@article{3683b0743f9c43af9c28eb7847061237,
title = "Regulation of In Situ to Invasive Breast Carcinoma Transition",
abstract = "The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal epithelial and myoepithelial cells identified an intricate interaction network involving TGFβ, Hedgehog, cell adhesion, and p63 required for myoepithelial cell differentiation, the elimination of which resulted in loss of myoepithelial cells and progression to invasion.",
keywords = "CELLBIO, CELLCYCLE",
author = "Min Hu and Jun Yao and Carroll, {Danielle K.} and Stanislawa Weremowicz and Haiyan Chen and Daniel Carrasco and Andrea Richardson and Shelia Violette and Tatiana Nikolskaya and Yuri Nikolsky and Bauerlein, {Erica L.} and Hahn, {William C.} and Gelman, {Rebecca S.} and Craig Allred and Bissell, {Mina J.} and Stuart Schnitt and Kornelia Polyak",
year = "2008",
month = "5",
day = "6",
doi = "10.1016/j.ccr.2008.03.007",
language = "English (US)",
volume = "13",
pages = "394--406",
journal = "Cancer Cell",
issn = "1535-6108",
publisher = "Cell Press",
number = "5",

}

TY - JOUR

T1 - Regulation of In Situ to Invasive Breast Carcinoma Transition

AU - Hu, Min

AU - Yao, Jun

AU - Carroll, Danielle K.

AU - Weremowicz, Stanislawa

AU - Chen, Haiyan

AU - Carrasco, Daniel

AU - Richardson, Andrea

AU - Violette, Shelia

AU - Nikolskaya, Tatiana

AU - Nikolsky, Yuri

AU - Bauerlein, Erica L.

AU - Hahn, William C.

AU - Gelman, Rebecca S.

AU - Allred, Craig

AU - Bissell, Mina J.

AU - Schnitt, Stuart

AU - Polyak, Kornelia

PY - 2008/5/6

Y1 - 2008/5/6

N2 - The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal epithelial and myoepithelial cells identified an intricate interaction network involving TGFβ, Hedgehog, cell adhesion, and p63 required for myoepithelial cell differentiation, the elimination of which resulted in loss of myoepithelial cells and progression to invasion.

AB - The transition of ductal carcinoma in situ (DCIS) to invasive carcinoma is a poorly understood key event in breast tumor progression. Here, we analyzed the role of myoepithelial cells and fibroblasts in the progression of in situ carcinomas using a model of human DCIS and primary breast tumors. Progression to invasion was promoted by fibroblasts and inhibited by normal myoepithelial cells. Molecular profiles of isolated luminal epithelial and myoepithelial cells identified an intricate interaction network involving TGFβ, Hedgehog, cell adhesion, and p63 required for myoepithelial cell differentiation, the elimination of which resulted in loss of myoepithelial cells and progression to invasion.

KW - CELLBIO

KW - CELLCYCLE

UR - http://www.scopus.com/inward/record.url?scp=42949121126&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=42949121126&partnerID=8YFLogxK

U2 - 10.1016/j.ccr.2008.03.007

DO - 10.1016/j.ccr.2008.03.007

M3 - Article

C2 - 18455123

AN - SCOPUS:42949121126

VL - 13

SP - 394

EP - 406

JO - Cancer Cell

JF - Cancer Cell

SN - 1535-6108

IS - 5

ER -