Regulation of protein metabolism in cancer

Cecil Han; Xiongbin Lu; Deepak Nagrath

doi:10.1080/23723556.2017.1285384

Regulation of protein metabolism in cancer

Cecil Han, Xiongbin Lu, Deepak Nagrath

Cancer Biology

Research output: Contribution to journal › Comment/debate › peer-review

9 Scopus citations

Abstract

Our recent studies determined molecular interactions between genes in the ubiquitin-proteasome pathways and cancer cell metabolism. Ubiquitin-specific peptidase 13 (USP13) specifically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase that drive ovarian cancer metabolism. These findings may lead to the development of USP13 inhibitors and new-targeted therapies in ovarian cancers.

Original language	English (US)
Article number	e1285384
Journal	Molecular and Cellular Oncology
Volume	5
Issue number	5
DOIs	https://doi.org/10.1080/23723556.2017.1285384
State	Published - Sep 3 2018

Keywords

ACLY
OGDH
USP13
cancer genomics
cancer metabolism
ovarian cancer

ASJC Scopus subject areas

Molecular Medicine
Cancer Research

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10.1080/23723556.2017.1285384

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title = "Regulation of protein metabolism in cancer",

abstract = "Our recent studies determined molecular interactions between genes in the ubiquitin-proteasome pathways and cancer cell metabolism. Ubiquitin-specific peptidase 13 (USP13) specifically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase that drive ovarian cancer metabolism. These findings may lead to the development of USP13 inhibitors and new-targeted therapies in ovarian cancers.",

keywords = "ACLY, OGDH, USP13, cancer genomics, cancer metabolism, ovarian cancer",

author = "Cecil Han and Xiongbin Lu and Deepak Nagrath",

note = "Publisher Copyright: {\textcopyright} 2018, {\textcopyright} 2018 Taylor & Francis Group, LLC.",

year = "2018",

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T1 - Regulation of protein metabolism in cancer

AU - Han, Cecil

AU - Lu, Xiongbin

AU - Nagrath, Deepak

PY - 2018/9/3

Y1 - 2018/9/3

N2 - Our recent studies determined molecular interactions between genes in the ubiquitin-proteasome pathways and cancer cell metabolism. Ubiquitin-specific peptidase 13 (USP13) specifically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase that drive ovarian cancer metabolism. These findings may lead to the development of USP13 inhibitors and new-targeted therapies in ovarian cancers.

AB - Our recent studies determined molecular interactions between genes in the ubiquitin-proteasome pathways and cancer cell metabolism. Ubiquitin-specific peptidase 13 (USP13) specifically deubiquitinates and thus upregulates ATP citrate lyase and oxoglutarate dehydrogenase that drive ovarian cancer metabolism. These findings may lead to the development of USP13 inhibitors and new-targeted therapies in ovarian cancers.

KW - ACLY

KW - OGDH

KW - USP13

KW - cancer genomics

KW - cancer metabolism

KW - ovarian cancer

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U2 - 10.1080/23723556.2017.1285384

DO - 10.1080/23723556.2017.1285384

M3 - Comment/debate

C2 - 30263935

AN - SCOPUS:85050959319

SN - 2372-3556

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JO - Molecular and Cellular Oncology

JF - Molecular and Cellular Oncology

IS - 5

M1 - e1285384

ER -

Regulation of protein metabolism in cancer

Abstract

Keywords

ASJC Scopus subject areas

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