TY - CHAP
T1 - Regulation of the Unfolded Protein Response in Cancer
AU - Zhang, Jing
AU - Koong, Albert C.
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 2010/8/31
Y1 - 2010/8/31
KW - ATF6 signaling branch of UPR - important ER stress sensor in promoter binding screen under ER stress
KW - Activation of UPR signaling branches in cancer
KW - ER stress induction, another mechanism of cell killing - by chemotherapeutic agents
KW - Endoplasmic reticulum (ER), key organelle - that can sense and trigger response to extracellular stresses
KW - Heterogeneous hypoxia regions, and insufficient and dysregulated tumor vasculature
KW - Hypoxia, common feature of microenvironment in solid tumors
KW - IRE1, only ER stress 'sensor' - conserved throughout all eukaryotic cells
KW - Regulation of unfolded protein response in cancer
KW - UPR signaling cascade - schematic representation of UPR signaling pathways
KW - UPR signaling-regulated genes
UR - http://www.scopus.com/inward/record.url?scp=84886038689&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84886038689&partnerID=8YFLogxK
U2 - 10.1002/9780470669891.ch13
DO - 10.1002/9780470669891.ch13
M3 - Chapter
AN - SCOPUS:84886038689
SN - 9780470749968
SP - 291
EP - 310
BT - Tumor Microenvironment
PB - John Wiley and Sons
ER -