Regulation of the Unfolded Protein Response in Cancer

Jing Zhang, Albert C. Koong

Research output: Chapter in Book/Report/Conference proceedingChapter

Original languageEnglish (US)
Title of host publicationTumor Microenvironment
PublisherJohn Wiley and Sons
Pages291-310
Number of pages20
ISBN (Print)9780470749968
DOIs
StatePublished - Aug 31 2010

Keywords

  • ATF6 signaling branch of UPR - important ER stress sensor in promoter binding screen under ER stress
  • Activation of UPR signaling branches in cancer
  • ER stress induction, another mechanism of cell killing - by chemotherapeutic agents
  • Endoplasmic reticulum (ER), key organelle - that can sense and trigger response to extracellular stresses
  • Heterogeneous hypoxia regions, and insufficient and dysregulated tumor vasculature
  • Hypoxia, common feature of microenvironment in solid tumors
  • IRE1, only ER stress 'sensor' - conserved throughout all eukaryotic cells
  • Regulation of unfolded protein response in cancer
  • UPR signaling cascade - schematic representation of UPR signaling pathways
  • UPR signaling-regulated genes

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology

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