Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

Wei Cao; Laura Bover; Minkwon Cho; Xiaoxia Wen; Shino Hanabuchi; Musheng Bao; David B. Rosen; Yi Hong Wang; Joanne L. Shaw; Qiumei Du; Chun Li; Naoko Arai; Zhengbin Yao; Lewis L. Lanier; Yong Jun Liu

doi:10.1084/jem.20090547

Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

Wei Cao, Laura Bover, Minkwon Cho, Xiaoxia Wen, Shino Hanabuchi, Musheng Bao, David B. Rosen, Yi Hong Wang, Joanne L. Shaw, Qiumei Du, Chun Li, Naoko Arai, Zhengbin Yao, Lewis L. Lanier, Yong Jun Liu

Research output: Contribution to journal › Article › peer-review

259 Scopus citations

Abstract

Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7-FcεRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion.

Original language	English (US)
Pages (from-to)	1603-1614
Number of pages	12
Journal	Journal of Experimental Medicine
Volume	206
Issue number	7
DOIs	https://doi.org/10.1084/jem.20090547
State	Published - Jul 6 2009

ASJC Scopus subject areas

Immunology and Allergy
Immunology

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10.1084/jem.20090547

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@article{24a7db48a97c4da5957c6a65a0c617e5,

title = "Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction",

abstract = "Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7-FcεRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion.",

author = "Wei Cao and Laura Bover and Minkwon Cho and Xiaoxia Wen and Shino Hanabuchi and Musheng Bao and Rosen, {David B.} and Wang, {Yi Hong} and Shaw, {Joanne L.} and Qiumei Du and Chun Li and Naoko Arai and Zhengbin Yao and Lanier, {Lewis L.} and Liu, {Yong Jun}",

year = "2009",

month = jul,

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doi = "10.1084/jem.20090547",

language = "English (US)",

volume = "206",

pages = "1603--1614",

journal = "Journal of Experimental Medicine",

issn = "0022-1007",

publisher = "Rockefeller University Press",

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T1 - Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

AU - Cao, Wei

AU - Bover, Laura

AU - Cho, Minkwon

AU - Wen, Xiaoxia

AU - Hanabuchi, Shino

AU - Bao, Musheng

AU - Rosen, David B.

AU - Wang, Yi Hong

AU - Shaw, Joanne L.

AU - Du, Qiumei

AU - Li, Chun

AU - Arai, Naoko

AU - Yao, Zhengbin

AU - Lanier, Lewis L.

AU - Liu, Yong Jun

PY - 2009/7/6

Y1 - 2009/7/6

N2 - Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7-FcεRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion.

AB - Plasmacytoid dendritic cells (pDCs) produce copious type I interferon (IFN) upon sensing nucleic acids through Toll-like receptor (TLR) 7 and TLR9. Uncontrolled pDC activation and IFN production are implicated in lymphopenia and autoimmune diseases; therefore, a mechanism controlling pDC IFN production is essential. Human pDCs specifically express an orphan receptor, immunoglobulin-like transcript 7 (ILT7). Here, we discovered an ILT7 ligand expressed by human cell lines and identified it as bone marrow stromal cell antigen 2 (BST2; CD317). BST2 directly binds to purified ILT7 protein, initiates signaling via the ILT7-FcεRIγ complex, and strongly inhibits production of IFN and proinflammatory cytokines by pDCs. Readily induced by IFN and other proinflammatory cytokines, BST2 may modulate the human pDC's IFN responses through ILT7 in a negative feedback fashion.

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Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

Abstract

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MD Anderson CCSG core facilities

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Regulation of TLR7/9 responses in plasmacytoid dendritic cells by BST2 and ILT7 receptor interaction

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MD Anderson CCSG core facilities

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