TY - JOUR
T1 - Regulators in the DNA damage response
AU - Liu, Yunhua
AU - Li, Yujing
AU - Lu, Xiongbin
N1 - Publisher Copyright:
© 2016 Elsevier Inc. All rights reserved.
Copyright:
Copyright 2018 Elsevier B.V., All rights reserved.
PY - 2016/3/15
Y1 - 2016/3/15
N2 - Maintenance of genome integrity is essential for the proper function of all cells and organisms. In response to both endogenous and exogenous DNA damaging agents, mammalian cells have evolved a delicate system to sense DNA damage, stop cell cycle progression, modulate cell metabolism, repair damaged DNA, and induce programmed cell death if the damage is too severe. This coordinated global signaling network, namely the DNA damage response (DDR), ensures the genome stability under DNA damaging stress. A variety of regulators have been shown to modulate the activity and levels of key proteins in the DDR, including kinases, phosphatases, ubiquitin ligases, deubiquitinases, and other protein modifying enzymes. Epigenetic regulators, particularly microRNAs and long noncoding RNAs, have been emerging as an important payer of regulation in addition to canonical DNA damage signaling proteins. In this review, we will discuss the functional interaction between the regulators and their targets in the DDR.
AB - Maintenance of genome integrity is essential for the proper function of all cells and organisms. In response to both endogenous and exogenous DNA damaging agents, mammalian cells have evolved a delicate system to sense DNA damage, stop cell cycle progression, modulate cell metabolism, repair damaged DNA, and induce programmed cell death if the damage is too severe. This coordinated global signaling network, namely the DNA damage response (DDR), ensures the genome stability under DNA damaging stress. A variety of regulators have been shown to modulate the activity and levels of key proteins in the DDR, including kinases, phosphatases, ubiquitin ligases, deubiquitinases, and other protein modifying enzymes. Epigenetic regulators, particularly microRNAs and long noncoding RNAs, have been emerging as an important payer of regulation in addition to canonical DNA damage signaling proteins. In this review, we will discuss the functional interaction between the regulators and their targets in the DDR.
KW - DNA damage response
KW - Long noncoding RNA
KW - Noncoding RNA
KW - Posttranslational modification
KW - microRNA
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U2 - 10.1016/j.abb.2016.02.018
DO - 10.1016/j.abb.2016.02.018
M3 - Review article
C2 - 26882840
AN - SCOPUS:84958985445
SN - 0003-9861
VL - 594
SP - 18
EP - 25
JO - Archives of Biochemistry and Biophysics
JF - Archives of Biochemistry and Biophysics
ER -