Reirradiation of Skull Base Tumors With Advanced Highly Conformal Techniques

Jennifer C. Ho, Jack Phan

Research output: Contribution to journalReview article

3 Scopus citations

Abstract

Purpose of Review: Skull base reirradiation is challenging due to complex anatomy, enrichment of treatment-resistant clonogens, and increased risk of severe treatment complications. Without local therapy, early mortality is certain and tumor progression can result in debilitating symptoms. Modern radiotherapy advancements, such as image-guided radiation therapy (IGRT), intensity-modulated radiation therapy (IMRT), particle therapy, and stereotactic radiation therapy (SRT), are attractive for skull base reirradiation. Recent Findings: Although limited by their retrospective nature and heterogeneous patient populations, several studies have demonstrated that reirradiation with these highly conformal techniques is feasible. Compared to IMRT or particle therapy reirradiation, SRT reirradiation appears promising with lower toxicity and increased convenience. Summary: Here, we provide thorough explanations for each technology and summarize the most relevant and recent studies, with particular attention to efficacy and toxicity. Skull base reirradiation using these extremely conformal therapy techniques requires meticulous treatment planning and should be delivered by experienced teams.

Original languageEnglish (US)
Article number82
JournalCurrent oncology reports
Volume19
Issue number12
DOIs
StatePublished - Dec 1 2017

Keywords

  • Head and neck cancer
  • Proton therapy
  • Radiosurgery
  • Reirradiation
  • Skull base
  • Stereotactic

ASJC Scopus subject areas

  • Oncology

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