Relationship between αvβ3 integrin and vasculogenic mimicry expression and related molecular mechanisms

Chunguang Pang, Baocun Sun, Xiulan Zhao, Zhiyong Liu, Qiang Gu, Xueyi Dong, Yuemei Ma, Dan Sun

    Research output: Contribution to journalArticle

    Abstract

    Objective: This work aimed to investigate the expression and clinical significance of vasculogenic mimicry (VM), to analyze the relationship between VM and αvβ3 integrin expressions, and to study the clinical significance of αvβ3 integrin expression and its correlation with the Focal Adhesion Kinase (FAK), Vascular Endothelial Growth Factor (VEGF), and Matrix Metalloproteinase 2 (MMP-2) expression. Methods: VM expression was observed by CD31 immunohistochemical and PAS staining. Expression of αvβ3 integrin, FAK, VEGF, and MMP-2 was observed by immunohistochemical staining. Results: Results showed that VM and αvβ3 integrin had positive rates of 18.06% (41/227) and 56.83% (129/227), respectively. Patients with VM expression had a shorter survival time than those without VM expression (P<0.05). αvβ3 integrin-positive patients had a shorter survival time than αvβ3 integrin-negative patients (P<0.05). Patients with VM expression showed a higher positive rate of αvβ3 integrin than those without VM expression (P<0.05), and αvβ3 integrin had a positive correlation with FAK, MMP-2, and VEGF expression. Conclusion: The incidence of VM and αvβ3 integrin expressions in human colorectal cancer cases indicates a poor prognosis. αvβ3 integrin possibly participates in the formation of VM through interactions with FAK, VEGF, and MMP-2.

    Original languageEnglish (US)
    Pages (from-to)555-559
    Number of pages5
    JournalChinese Journal of Clinical Oncology
    Volume40
    Issue number10
    DOIs
    StatePublished - May 30 2013

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    Keywords

    • Clinical prognosis
    • Colorectal cancer
    • Molecular mechanism
    • Vasculogenic mimicry
    • αvβ3 integrin

    ASJC Scopus subject areas

    • Oncology
    • Cancer Research

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