Relationship between treatment center case volume and survival for localized Ewing sarcoma: The role of radiotherapy timing

Timothy A. Lin; Ethan B. Ludmir; Kai Ping Liao; Mary Frances McAleer; Andrew J. Bishop; David Grosshans; Susan McGovern; Kristina D. Woodhouse; Arnold C. Paulino; Debra Nana Yeboa

doi:10.1002/pbc.28685

Relationship between treatment center case volume and survival for localized Ewing sarcoma: The role of radiotherapy timing

Timothy A. Lin, Ethan B. Ludmir, Kai Ping Liao, Mary Frances McAleer, Andrew J. Bishop, David Grosshans, Susan McGovern, Kristina D. Woodhouse, Arnold C. Paulino, Debra Nana Yeboa

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

In the treatment of localized Ewing sarcoma (EWS), delays in local therapy are known to adversely impact overall survival (OS). However, the role of treatment center volume in EWS outcomes, and the interaction between center volume and local therapy timing with definitive radiotherapy, remains unknown. Using the National Cancer Database, we demonstrate that treatment at the lowest EWS volume centers is associated with reduced OS, explained partly by higher rates of delayed local therapy. Treatment at the highest volume centers results in improved OS, but appears independent of radiotherapy timing. Future efforts to improve care for EWS patients across treatment centers are imperative.

Original language	English (US)
Article number	e28685
Journal	Pediatric Blood and Cancer
Volume	67
Issue number	11
DOIs	https://doi.org/10.1002/pbc.28685
State	Published - Nov 1 2020

Keywords

Ewing's sarcoma
health services
radiation therapy

ASJC Scopus subject areas

Pediatrics, Perinatology, and Child Health
Hematology
Oncology

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10.1002/pbc.28685

Cite this

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title = "Relationship between treatment center case volume and survival for localized Ewing sarcoma: The role of radiotherapy timing",

abstract = "In the treatment of localized Ewing sarcoma (EWS), delays in local therapy are known to adversely impact overall survival (OS). However, the role of treatment center volume in EWS outcomes, and the interaction between center volume and local therapy timing with definitive radiotherapy, remains unknown. Using the National Cancer Database, we demonstrate that treatment at the lowest EWS volume centers is associated with reduced OS, explained partly by higher rates of delayed local therapy. Treatment at the highest volume centers results in improved OS, but appears independent of radiotherapy timing. Future efforts to improve care for EWS patients across treatment centers are imperative.",

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doi = "10.1002/pbc.28685",

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T1 - Relationship between treatment center case volume and survival for localized Ewing sarcoma

T2 - The role of radiotherapy timing

AU - Lin, Timothy A.

AU - Ludmir, Ethan B.

AU - Liao, Kai Ping

AU - McAleer, Mary Frances

AU - Bishop, Andrew J.

AU - Grosshans, David

AU - McGovern, Susan

AU - Woodhouse, Kristina D.

AU - Paulino, Arnold C.

AU - Yeboa, Debra Nana

PY - 2020/11/1

Y1 - 2020/11/1

N2 - In the treatment of localized Ewing sarcoma (EWS), delays in local therapy are known to adversely impact overall survival (OS). However, the role of treatment center volume in EWS outcomes, and the interaction between center volume and local therapy timing with definitive radiotherapy, remains unknown. Using the National Cancer Database, we demonstrate that treatment at the lowest EWS volume centers is associated with reduced OS, explained partly by higher rates of delayed local therapy. Treatment at the highest volume centers results in improved OS, but appears independent of radiotherapy timing. Future efforts to improve care for EWS patients across treatment centers are imperative.

AB - In the treatment of localized Ewing sarcoma (EWS), delays in local therapy are known to adversely impact overall survival (OS). However, the role of treatment center volume in EWS outcomes, and the interaction between center volume and local therapy timing with definitive radiotherapy, remains unknown. Using the National Cancer Database, we demonstrate that treatment at the lowest EWS volume centers is associated with reduced OS, explained partly by higher rates of delayed local therapy. Treatment at the highest volume centers results in improved OS, but appears independent of radiotherapy timing. Future efforts to improve care for EWS patients across treatment centers are imperative.

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Relationship between treatment center case volume and survival for localized Ewing sarcoma: The role of radiotherapy timing

Abstract

Keywords

ASJC Scopus subject areas

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